Mammals have two specialized vascular circulatory systems: the blood vasculature and the
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …

The lymphatic system (LS) is composed of lymphoid organs and a network of vessels that
transport interstitial fluid, antigens, lipids, cholesterol, immune cells, and other materials in …

Patients with bladder cancer (BCa) with clinical lymph node (LN) metastasis have an
extremely poor prognosis. VEGF-C has been demonstrated to play vital roles in LN …

A genuine and functional lymphatic vascular system is found in the meninges that sheath the
central nervous system (CNS). This unexpected (re) discovery led to a reevaluation of CNS …

The lymphatic vasculature requires intraluminal valves to maintain forward lymph flow.
Lymphatic valves form and are constantly maintained by oscillatory fluid flow throughout life …

The lymphatic vasculature has a pivotal role in regulating body fluid homeostasis, immune
surveillance and dietary fat absorption. The increasing number of in vitro and in vivo studies …

Background Microvascular dysfunction plays an important role in the pathogenesis of heart
failure with preserved ejection fraction (HFpEF). However, no mechanistic link between …

The lymphatic vascular system acts as the major transportation highway of tissue fluids, and
its activation or impairment is associated with a wide range of diseases. There has been …

During the growth of lymphatic vessels (lymphangiogenesis), lymphatic endothelial cells
(LECs) at the growing front sprout by forming filopodia. Those tip cells are not exposed to …

Alzheimer's disease (AD) is a prevalent neurodegenerative disease characterized by
cognitive decline and learning/memory impairment associated with neuronal cell loss …