Dual therapy (pegylated interferon plus ribavirin) was considered the standard of care for
hepatitis C virus (HCV) treatment until 2011, when the first-wave direct-acting antivirals were …

Hepatitis C virus (HCV) has emerged as a major viral pandemic over the past two decades,
infecting 170 million individuals, which equates to approximately 3% of the world's …

Background There is growing evidence that variations in the gene encoding inosine
triphosphate pyrophosphohydrolase (ITPase), known as inosine triphosphatase (ITPA), are …

Hepatitis C virus (HCV) chronically infects 170 million people worldwide. Until recently,
combination therapy with peginterferon‐α (peg IFN) and ribavirin (RBV) has been the …

Background: Single-nucleotide polymorphisms (SNP) in the inosine triphosphate
pyrophosphatase (ITPA) gene correlate with ribavirin (RBV)-induced anemia in patients with …

GONZALEZ-ALDACO, Karina et al. High Prevalence of ITPA Alleles Associated with
Ribavirin-Induced Hemolytic Anemia Among Mexican Population. Ann. Hepatol.[online] …

Objective Infertility is a common human disorder which is defined as the failure to conceive
for a period of 12 months without contraception. Many studies have shown that the outcome …

THA complications in patients with human immunodeficiency virus (HIV) and Hepatitis C
(HCV) coinfection. The topic is important because these patients often have reduced bone …

AIM: To analyzed the association between inosine triphosphatase (ITPA)(rs1127354)
genotypes and sustained virological response (SVR) rates in peginterferon (Peg-IFN) α+ …

This review will summarize the role of pharmacogenetics in the natural history of hepatitis C,
particularly in patients with HIV/HCV and will take the perspective of pharmacogenetics and …