Decoding polygenic diseases: advances in noncoding variant prioritization and validation

IM Chin, ZA Gardell, MR Corces - Trends in Cell Biology, 2024 - cell.com
Genome-wide association studies (GWASs) provide a key foundation for elucidating the
genetic underpinnings of common polygenic diseases. However, these studies have …

Decoding biology with massively parallel reporter assays and machine learning

A La Fleur, Y Shi, G Seelig - Genes & Development, 2024 - genesdev.cshlp.org
Massively parallel reporter assays (MPRAs) are powerful tools for quantifying the impacts of
sequence variation on gene expression. Reading out molecular phenotypes with …

MPRAVarDB: an online database and web server for exploring regulatory effects of genetic variants

W Jin, Y Xia, J Nizomov, Y Liu, Z Li, Q Lu… - Bioinformatics, 2024 - academic.oup.com
Massively parallel reporter assay (MPRA) is an important technology for evaluating the
impact of genetic variants on gene regulation. Here, we present MPRAVarDB, an online …

[HTML][HTML] MPRAVarDB: an online database and web server for exploring regulatory effects of genetic variants

J Nizomov, W Jin, Y Xia, Y Liu, Z Li, L Chen - bioRxiv, 2024 - ncbi.nlm.nih.gov
Massively parallel reporter assay (MPRA) is an important technology to evaluate the impact
of genetic variants on gene regulation. Here, we present MPRAVarDB, an online database …

MPRAVarDB: an online database and web server for exploring regulatory effects of genetic variants

N Javlon, W Jin, Y Xia, Y Liu, Z Li, L Chen - bioRxiv, 2024 - biorxiv.org
Massively parallel reporter assay (MPRA) is an important technology to evaluate the impact
of genetic variants on gene regulation. Here, we present MPRAVarDB, an online database …