Thyroid hormone (TH) molecules enter cells via membrane transporters and, depending on
the cell type, can be activated (ie, T4 to T3 conversion) or inactivated (ie, T3 to 3, 3′-diiodo-l …

Iodothyronine deiodinases (DIO) are a family of selenoproteins controlling systemic and
local availability of the major thyroid hormone l-thyroxine (T4), a prohormone secreted by the …

Thyroid hormone (TH) is critical for the maintenance of cellular homeostasis during stress
responses, but its role in lung fibrosis is unknown. Here we found that the activity and …

While bile acids (BAs) have long been known to be essential in dietary lipid absorption and
cholesterol catabolism, in recent years an important role for BAs as signalling molecules has …

The thyroid hormone triiodothyronine (T3) activates thermogenesis by uncoupling electron
transport from ATP synthesis in brown adipose tissue (BAT) mitochondria. Although T3 can …

Brown adipose tissue (BAT) dissipates energy as heat to maintain optimal thermogenesis
and to contribute to energy expenditure in rodents and possibly humans. The energetic …

The iodothyronine deiodinases initiate or terminate thyroid hormone action and therefore
are critical for the biological effects mediated by thyroid hormone. Over the years, research …

The deiodinases activate or inactivate thyroid hormone, and their importance in thyroid
hormone homeostasis has become increasingly clear with the availability of deiodinase …

Background: Clustering of various metabolic parameters including abdominal obesity,
hyperglycaemia, low high-density lipoprotein cholesterol, elevated triglycerides and …

Recent identification of new selenocysteine-containing proteins has revealed relationships
between the two trace elements selenium (Se) and iodine and the hormone network …