Surface modification of lipid-based nanoparticles

Y Xu, T Fourniols, Y Labrak, V Préat, A Beloqui… - ACS …, 2022 - ACS Publications
There is a growing interest in the development of lipid-based nanocarriers for multiple
purposes, including the recent increase of these nanocarriers as vaccine components …

PEGylation for enhancing nanoparticle diffusion in mucus

JT Huckaby, SK Lai - Advanced drug delivery reviews, 2018 - Elsevier
The viscoelastic mucus secretions coating exposed organs such as the lung airways and the
female reproductive tract can trap and quickly eliminate not only foreign pathogens and …

Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues

SK Lai, YY Wang, J Hanes - Advanced drug delivery reviews, 2009 - Elsevier
Mucus is a viscoelastic and adhesive gel that protects the lung airways, gastrointestinal (GI)
tract, vagina, eye and other mucosal surfaces. Most foreign particulates, including …

Cystic fibrosis: a mucosal immunodeficiency syndrome

TS Cohen, A Prince - Nature medicine, 2012 - nature.com
Cystic fibrosis transmembrane conductance regulator (CFTR) functions as a channel that
regulates the transport of ions and the movement of water across the epithelial barrier …

Toxicity of cellulose nanocrystals: a review

M Roman - Industrial Biotechnology, 2015 - liebertpub.com
Cellulose nanocrystals (CNCs) are a biobased nanomaterial attracting increasing interest
for a range of potential applications. This article reviews the current literature on the …

Pathophysiology and management of pulmonary infections in cystic fibrosis

RL Gibson, JL Burns, BW Ramsey - American journal of respiratory …, 2003 - atsjournals.org
This comprehensive State of the Art review summarizes the current published knowledge
base regarding the pathophysiology and microbiology of pulmonary disease in cystic …

Nutritional Cues Control Pseudomonas aeruginosa Multicellular Behavior in Cystic Fibrosis Sputum

KL Palmer, LM Aye, M Whiteley - Journal of bacteriology, 2007 - Am Soc Microbiol
The sputum (mucus) layer of the cystic fibrosis (CF) lung is a complex substrate that provides
Pseudomonas aeruginosa with carbon and energy to support high-density growth during …

Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice

M Mall, BR Grubb, JR Harkema, WK O'Neal… - Nature medicine, 2004 - nature.com
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene result in
defective epithelial cAMP-dependent Cl− secretion and increased airway Na+ absorption …

Airway acidification initiates host defense abnormalities in cystic fibrosis mice

VS Shah, DK Meyerholz, XX Tang, L Reznikov… - Science, 2016 - science.org
Cystic fibrosis (CF) is caused by mutations in the gene that encodes the cystic fibrosis
transmembrane conductance regulator (CFTR) anion channel. In humans and pigs, the loss …

N-acylhomoserine lactones undergo lactonolysis in a pH-, temperature-, and acyl chain length-dependent manner during growth of Yersinia pseudotuberculosis and …

EA Yates, B Philipp, C Buckley, S Atkinson… - Infection and …, 2002 - Am Soc Microbiol
In gram-negative bacterial pathogens, such as Pseudomonas aeruginosa and Yersinia
pseudotuberculosis, cell-to-cell communication via the N-acylhomoserine lactone (AHL) …