Tissue engineering and regenerative medicine involve many different artificial and biologic
materials, frequently integrated in composite scaffolds, which can be repopulated with …

The goal of tissue engineering is to mitigate the critical shortage of donor organs via in vitro
fabrication of functional biological structures. Tissue engineering is one of the most …

Rationale: Stem cell–based tracheal replacement represents an emerging therapeutic
option for patients with otherwise untreatable airway diseases including long-segment …

OBJECTIVES Currently, most of the artificial airway organs still require scaffolds; however,
such scaffolds exhibit several limitations. Alternatively, the use of an autologous artificial …

Effective restoration of extensive tracheal damage arising from cancer, stenosis, infection or
congenital abnormalities remains an unmet clinical need in respiratory medicine. The …

Collagen and collagen-based materials have been successfully used in medicine for over
50 years. The number of scientific articles about the role of collagen in the construction of …

Importance Airway transplantation could be an option for patients with proximal lung tumor
or with end-stage tracheobronchial disease. New methods for airway transplantation remain …

The worldwide shortage of organs fosters significant advancements in regenerative
therapies. Tissue engineering and regeneration aim to supply or repair organs or tissues by …

Tracheal replacement is performed after resection of a portion of the trachea that was
impossible to reconnect via direct anastomosis. A tissue-engineered trachea is one of the …

Over the past 25 years, we have demonstrated the feasibility of airway bioengineering using
stented aortic matrices experimentally then in a first‐in‐human trial (n= 13). The present …