Urothelial carcinoma of the bladder comprises two long-recognized disease entities with
distinct molecular features and clinical outcome. Low-grade non-muscle-invasive tumours …

The pluripotent state of embryonic stem cells (ESCs) is produced by active transcription of
genes that control cell identity and repression of genes encoding lineage-specifying …

In the interphase of the cell cycle, chromatin is arranged in a hierarchical structure within the
nucleus,, which has an important role in regulating gene expression,,–. However, the …

Chromatin looping is important for gene regulation, and studies of 3D chromatin structure
across species and cell types have improved our understanding of the principles governing …

Acute myeloid leukemia (AML) affects tens of thousands of patients a year, yet survival rates
are as low as 25% in certain populations. This poor survival rate is partially due to the vast …

Epstein-Barr virus (EBV) immortalization of resting B lymphocytes (RBLs) to lymphoblastoid
cell lines (LCLs) models human DNA tumor virus oncogenesis. RBL and LCL chromatin …

Acute myelogenous leukemia (AML) is a high-risk hematopoietic malignancy caused by a
variety of mutations, including genes encoding the cohesin complex. Recent studies have …

Successfully completing the S phase of each cell cycle ensures genome integrity.
Impediment of DNA replication can lead to DNA damage and genomic disorders. In this …

The study of the three-dimensional organization of chromatin has recently gained much
focus in the context of novel techniques for detecting genome-wide contacts using next …

Dominated by microscopy for decades the nuclear genome organization field has recently
undergone a dramatic transition fuelled by new next generation sequencing technologies …