Hox genes encode homeodomain transcription factors that control morphogenesis and have
established functions in development and evolution. Hox proteins have remained enigmatic …

Homeobox genes (HOX) are a large family of transcription factors that direct the formation of
many body structures during early embryonic development. There are 39 genes in the …

Despite the high incidence of male infertility, only 30% of infertile men receive a causative
diagnosis. To explore the regulatory mechanisms governing human germ cell function in …

The histone lysine demethylase KDM4C is often overexpressed in cancers primarily through
gene amplification. The molecular mechanisms of KDM4C action in tumorigenesis are not …

Precision-cut slices of in vivo tumours permit interrogation in vitro of heterogeneous cells
from solid tumours together with their native microenvironment. They offer a low throughput …

We present an integrative genome-wide analysis that can be used to predict the risk of
progression from leukoplakia to oral squamous cell carcinoma (OSCC) arising in the …

Chemoresistance prevents the curative cancer chemotherapy and presents a formidable
challenge for both cancer researchers and clinicians. We have previously shown that miR …

Chemotherapy is an important cancer treatment method. Tumor chemotherapy resistance is
one of the main factors leading to tumor progression. Like other malignancies, bladder …

MEIS2 has an important role in development and organogenesis, and is implicated in the
pathogenesis of human cancer. The molecular basis of MEIS2 action in tumorigenesis is not …

High-risk neuroblastoma remains one of the deadliest childhood cancers. Identification of
metabolic pathways that drive or maintain high-risk neuroblastoma may open new avenues …