CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …

Sound pressure fluctuations striking the ear are conveyed to the cochlea, where they vibrate
the basilar membrane on which sit hair cells, the mechanoreceptors of the inner ear …

Progressive functional deterioration in the cochlea is associated with age-related hearing
loss (ARHL). However, the cellular and molecular basis underlying cochlear aging remains …

The pharmacologic profile of retigabine [RTG (international nonproprietary name);
ezogabine, EZG (US adopted name)], is different from all currently approved antiepileptic …

Neuronal Kv7 channels underlie a voltage-gated non-inactivating potassium current known
as the M-current. Due to its particular characteristics, Kv7 channels show pronounced …

Outer hair cells (OHCs) provide amplification in the mammalian cochlea using somatic force
generation underpinned by voltage-dependent conformational changes of the motor protein …

Outer hair cell (OHC) degeneration is a major cause of progressive hearing loss and
presbycusis. Despite the high prevalence of these disorders, targeted therapy is currently …

Gene therapy would benefit from the effective editing of targeted cells with CRISPR-Cas9
tools. However, it is difficult to precisely assess the editing performance in vivo because the …

Sensory transduction in the cochlea and vestibular labyrinth depends on fluid movements
that deflect the hair bundles of mechanosensitive hair cells. Mechanosensitive transducer …

Hearing loss (HL), or deafness in its most severe form, affects an estimated 28 and 22.5
million Americans and Europeans, respectively. The numbers are higher in regions such as …