Across the animal kingdom there are myriad forms within a sex across, and even within,
species, rendering concepts of universal sex traits moot. The mechanisms that regulate the …

Estrogen receptor alpha (ER/ESR1) mutations occur in 30% to 40% of endocrine resistant
ER-positive (ER+) breast cancer. Forkhead box A1 (FOXA1) is a key pioneer factor …

Sexual dimorphism often results from hormonally regulated trait differences between the
sexes. In sex-role-reversed vertebrates, females often have ornaments used in mating …

Although it is well established that sexual selection can shape sex-biased phenotypes, there
is growing interest in the impacts of sexual selection on the genomic architecture (Mank …

Introduction Natural and synthetic estrogens are pollutants found in aquatic ecosystems at
low concentrations reaching ng. L-1 to μg. L-1. At these concentrations, they are able to …

Genomics is a sequence-based informatics science and a three-dimensional-structure-
based material science. However, in practice, most genomics researchers utilize sequence …

In males of many vertebrate species, sexual selection has led to the evolution of sexually
dimorphic traits, which are often developmentally controlled by androgen signaling involving …

In this dissertation, a framework for multi-dimensional and multi-scale modeling is proposed.
The essential idea is based on oriented space curves, which can be represented as a 3D …

Hotspot mutations in the estrogen receptor alpha (ERα) are frequently detected in ER+
metastatic breast cancer. There is increasing evidence that these mutations confer …