Modulation of endogenous cellular defense mechanisms represents an innovative approach
to therapeutic intervention in diseases causing chronic tissue damage, such as in …

1. ABSTRACT A large body of evidence points to the positive effects of dietary
supplementation of acetyl-L-carnitine (ALC). Its use has shown health benefits in …

Neuropathic syndromes which are evoked by lesions to the peripheral or central nervous
system are extremely difficult to treat, and available drugs rarely joint an antihyperalgesic …

Oxaliplatin is a platinum-organic drug with antineoplastic properties used for colorectal
cancer. With respect to the other platinum derivates oxaliplatin induces only a mild …

Chronic pain is a common, complex and unpleasant sensation following nerve injury, tissue
trauma, inflammatory diseases, infection and cancer. It affects up to 25% of adults and is …

Abstract Acetyl-L-carnitine (ALC) has shown a neuroprotective effect in patients with
peripheral neuropathies of different etiologies. Preclinical studies demonstrated a central …

Oxaliplatin, unlike other platinum anticancer agents, has only mild toxic effects on the
hematopoietic, urinary and gastrointestinal systems. Its dose-limiting side effect is …

Analyzing Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis: Potential Role of L-carnitine
Page 1 KIDNEY DISEASES 74 R eview Iranian Journal of Kidney Diseases | Volume 13 …

Despite numerous studies reporting some measures of efficacy in the animal literature, there
are currently no effective therapies for the treatment of traumatic spinal cord injuries (SCI) in …

The widely accepted oxidative stress theory of aging postulates that aging results from
accumulation of oxidative damage. A prediction of this theory is that, among species …