[HTML][HTML] mTORC1 beyond anabolic metabolism: Regulation of cell death

J Zhu, H Wang, X Jiang - Journal of Cell Biology, 2022 - rupress.org
The mechanistic target of rapamycin complex 1 (mTORC1), a multi-subunit protein kinase
complex, interrogates growth factor signaling with cellular nutrient and energy status to …

Regulation of autophagy by the glycogen synthase kinase-3 (GSK-3) signaling pathway

HY Pan, M Valapala - International Journal of Molecular Sciences, 2022 - mdpi.com
Autophagy is a vital cellular mechanism that benefits cellular maintenance and survival
during cell stress. It can eliminate damaged or long-lived organelles and improperly folded …

Generation and application of novel hES cell reporter lines for the differentiation and maturation of hPS cell-derived islet-like clusters

E Zanfrini, M Bandral, L Jarc, MA Ramirez-Torres… - Scientific Reports, 2024 - nature.com
The significant advances in the differentiation of human pluripotent stem (hPS) cells into
pancreatic endocrine cells, including functional β-cells, have been based on a detailed …

Roles of mTOR in the regulation of pancreatic β-cell mass and insulin secretion

S Asahara, H Inoue, H Watanabe, Y Kido - Biomolecules, 2022 - mdpi.com
Pancreatic β-cells are the only type of cells that can control glycemic levels via insulin
secretion. Thus, to explore the mechanisms underlying pancreatic β-cell failure, many …

Apoptosis in type 2 diabetes: Can it be prevented? Hippo pathway prospects

A Kilanowska, A Ziółkowska - International Journal of Molecular Sciences, 2022 - mdpi.com
Diabetes mellitus is a heterogeneous disease of complex etiology and pathogenesis.
Hyperglycemia leads to many serious complications, but also directly initiates the process of …

Nobiletin Alleviated Epithelial–Mesenchymal Transition of Hepatocytes in Liver Fibrosis Based on Autophagy—Hippo/YAP Pathway

Y Hao, D Feng, H Ye, W Liao - Molecular Nutrition & Food …, 2024 - Wiley Online Library
Scope The current researches indicated that the epithelial–mesenchymal transition (EMT) of
hepatocytes plays a crucial role in the development of liver fibrosis. To date, there is a …

[HTML][HTML] Necroptosis throws novel insights on patient classification and treatment strategies for hepatocellular carcinoma

B Hu, J Gao, J Shi, F Zhang, C Shi, P Wen… - Frontiers in …, 2022 - frontiersin.org
Introduction Necroptosis is a novel pattern of immunogenic cell death and has triggered an
emerging wave in antitumor therapy. More evidence has suggested the potential …

Regulation of autophagy and cellular signaling through non-histone protein methylation

Y Bao, Y Ma, W Huang, Y Bai, S Gao, L Xiu… - International Journal of …, 2024 - Elsevier
Autophagy is a highly conserved catabolic pathway that is precisely regulated and plays a
significant role in maintaining cellular metabolic balance and intracellular homeostasis …

Insights on the role of anti-inflammatory and immunosuppressive agents in the amelioration of diabetes

U Rai, D Senapati, MK Arora - Diabetology international, 2023 - Springer
Diabetes is a major health problem worldwide. It is a chronic metabolic disorder that
produces overt hyperglycemic condition that occurs either when the pancreas does not …

[HTML][HTML] Endoplasmic reticulum stress mechanisms and exercise intervention in type 2 diabetes mellitus

Q Chen, X Zhao, Z Xu, Y Liu - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Type 2 diabetes mellitus (T2DM) is a metabolic disease primarily characterized by insulin
resistance (IR) and insufficient insulin secretion. The unfolded protein response (UPR) …