Metastatic heterogeneity of breast cancer: Molecular mechanism and potential therapeutic targets
Breast cancer is one of the most common malignancies among women throughout the world
and is the major cause of most cancer-related deaths. Several explanations account for the …
and is the major cause of most cancer-related deaths. Several explanations account for the …
Brain metastases
AS Achrol, RC Rennert, C Anders, R Soffietti… - Nature Reviews …, 2019 - nature.com
An estimated 20% of all patients with cancer will develop brain metastases, with the majority
of brain metastases occurring in those with lung, breast and colorectal cancers, melanoma …
of brain metastases occurring in those with lung, breast and colorectal cancers, melanoma …
Breast cancer brain metastasis: molecular mechanisms and directions for treatment
RMSM Pedrosa, DA Mustafa, R Soffietti… - Neuro …, 2018 - academic.oup.com
The development of brain metastasis (BM) of breast cancer is usually a late event with
deleterious effect on the prognosis. Treatment options for intracerebral seeding of breast …
deleterious effect on the prognosis. Treatment options for intracerebral seeding of breast …
Tyrosine kinase inhibitors for brain metastases in HER2-positive breast cancer
R Duchnowska, S Loibl, J Jassem - Cancer treatment reviews, 2018 - Elsevier
Abstract Approximately 30–50% of advanced HER2-positive breast cancer patients will
develop central nervous system (CNS) metastases, with an annual risk of around 10%, and …
develop central nervous system (CNS) metastases, with an annual risk of around 10%, and …
[HTML][HTML] Risk factors for breast cancer brain metastases: a systematic review
L Koniali, A Hadjisavvas, A Constantinidou… - Oncotarget, 2020 - ncbi.nlm.nih.gov
Background: Brain metastasis (BM) is an increasingly common and devastating
complication of breast cancer (BC). Methods: A systematic literature search of EMBASE and …
complication of breast cancer (BC). Methods: A systematic literature search of EMBASE and …
Prognostic factors of brain metastasis and survival among HER2-positive metastatic breast cancer patients: a systematic literature review
MD Hackshaw, HE Danysh, M Henderson, E Wang… - Bmc Cancer, 2021 - Springer
Background Patients with breast cancer who overexpress the human epidermal growth
factor receptor 2 (HER2) and subsequently develop brain metastasis (BM) typically …
factor receptor 2 (HER2) and subsequently develop brain metastasis (BM) typically …
Association between AT1 and AT2 angiotensin II receptor expression with cell proliferation and angiogenesis in operable breast cancer
O Arrieta, C Villarreal-Garza, G Vizcaíno, B Pineda… - Tumor Biology, 2015 - Springer
Angiotensin II (ANGII) has been associated with vascular proliferation in tumor and non-
tumor models through its receptors AT1 and AT2. Our objective was to determine AT1 and …
tumor models through its receptors AT1 and AT2. Our objective was to determine AT1 and …
[HTML][HTML] miR-20b is up-regulated in brain metastases from primary breast cancers
Brain metastases are frequent in patients with advanced breast cancer and are associated
with poor prognosis. However, unique molecular biomarkers have not yet been established …
with poor prognosis. However, unique molecular biomarkers have not yet been established …
A comparison of DNA mutation and copy number profiles of primary breast cancers and paired brain metastases for identifying clinically relevant genetic alterations in …
M Tyran, N Carbuccia, S Garnier, A Guille, J Adelaïde… - Cancers, 2019 - mdpi.com
Improving the systemic treatment of brain metastases (BM) in primary breast cancer (PBC) is
impaired by the lack of genomic characterization of BM. To estimate the concordance of …
impaired by the lack of genomic characterization of BM. To estimate the concordance of …
Molecular aspects of brain metastases in breast cancer
B Tomasik, M Bieńkowski, Z Górska, K Gutowska… - Cancer Treatment …, 2023 - Elsevier
Brain metastases (BM) are a common and devastating manifestation of breast cancer (BC).
BM are particularly frequent in the HER2-positive and triple-negative breast cancer …
BM are particularly frequent in the HER2-positive and triple-negative breast cancer …