The pathogenesis of hypertension is known to involve a diverse range of contributing factors
including genetic, environmental, hormonal, hemodynamic and inflammatory forces, to …

Serum urate has been implicated in hypertension and cardiovascular disease, but it is not
known whether it is exerting a causal effect. To investigate this, we performed Mendelian …

Importance An estimated 40% of dementia is potentially preventable by modifying 12 risk
factors throughout the life course. However, robust evidence for most of these risk factors is …

Aims Inflammation is an important driver of hypertension. Periodontitis is a chronic
inflammatory disease, which could provide a mechanism for pro-hypertensive immune …

Background: High blood pressure (BP) is a risk factor for cardiovascular morbidity and
mortality. While BP is regulated by the function of kidney, vasculature, and sympathetic …

Background: Calcific aortic stenosis (CAS) is the most common valvular heart disease in
older adults and has no effective preventive therapies. Genome-wide association studies …

Background: Heart failure (HF) is a highly prevalent disorder for which disease mechanisms
are incompletely understood. The discovery of disease-associated proteins with causal …

There is increasing evidence of the influence of the gut microbiota on hypertension and its
complications, such as chronic kidney disease, stroke, heart failure, and myocardial …

Importance Hypertensive disorders in pregnancy (HDPs) are major causes of maternal and
fetal morbidity and are observationally associated with future maternal risk of cardiovascular …

Background: Recent clinical guidelines support intensive blood pressure treatment targets.
However, observational data suggest that excessive diastolic blood pressure (DBP) …