The role of flavonoids in autoimmune diseases: Therapeutic updates
Flavonoids are natural polyphenolic compounds which are included in a panoply of drugs
and used to treat and/or manage human ailments such as metabolic, cardiovascular …
and used to treat and/or manage human ailments such as metabolic, cardiovascular …
[HTML][HTML] Emerging roles for IL-11 in inflammatory diseases
Abstract Interleukin-11 (IL-11) is a cytokine that has been strongly implicated in the
pathogenesis of fibrotic diseases and solid malignancies. Elevated IL-11 expression is also …
pathogenesis of fibrotic diseases and solid malignancies. Elevated IL-11 expression is also …
Effect of secukinumab on clinical and radiographic outcomes in ankylosing spondylitis: 2-year results from the randomised phase III MEASURE 1 study
J Braun, X Baraliakos, A Deodhar, D Baeten… - Annals of the …, 2017 - ard.bmj.com
Objective To evaluate the effect of secukinumab, an interleukin-17A inhibitor, on clinical
signs and symptoms and radiographic changes through 2 years in patients with ankylosing …
signs and symptoms and radiographic changes through 2 years in patients with ankylosing …
A phase II randomized study of subcutaneous ixekizumab, an anti–interleukin‐17 monoclonal antibody, in rheumatoid arthritis patients who were naive to biologic …
MC Genovese, M Greenwald, CS Cho… - Arthritis & …, 2014 - Wiley Online Library
Objective To evaluate ixekizumab, an anti–interleukin‐17A (anti–IL‐17A) monoclonal
antibody, in 2 populations of rheumatoid arthritis (RA) patients: biologics‐naive patients and …
antibody, in 2 populations of rheumatoid arthritis (RA) patients: biologics‐naive patients and …
Bone loss triggered by the cytokine network in inflammatory autoimmune diseases
DS Amarasekara, J Yu, J Rho - Journal of immunology research, 2015 - Wiley Online Library
Bone remodeling is a lifelong process in vertebrates that relies on the correct balance
between bone resorption by osteoclasts and bone formation by osteoblasts. Bone loss and …
between bone resorption by osteoclasts and bone formation by osteoblasts. Bone loss and …
Cytokine‐mediated bone destruction in rheumatoid arthritis
SM Jung, KW Kim, CW Yang… - Journal of immunology …, 2014 - Wiley Online Library
Bone homeostasis, which involves formation and resorption, is an important process for
maintaining adequate bone mass in humans. Rheumatoid arthritis (RA) is an autoimmune …
maintaining adequate bone mass in humans. Rheumatoid arthritis (RA) is an autoimmune …
[HTML][HTML] Th17 cytokines regulate osteoclastogenesis in rheumatoid arthritis
This study determined the effect of type 17 helper T-cell (Th17) cytokines on
osteoclastogenesis in rheumatoid arthritis (RA). The expression of IL-17 and receptor …
osteoclastogenesis in rheumatoid arthritis (RA). The expression of IL-17 and receptor …
Quercetin attenuates collagen-induced arthritis by restoration of Th17/Treg balance and activation of Heme Oxygenase 1-mediated anti-inflammatory effect
Y Yang, X Zhang, M Xu, X Wu, F Zhao… - International …, 2018 - Elsevier
Quercetin (QU) has been shown obvious anti-arthritic property in pre-clinical studies or
clinical studies. Howbeit, the underlying mechanism of it is still not revealed distinctly and …
clinical studies. Howbeit, the underlying mechanism of it is still not revealed distinctly and …
IL-23 is critical for induction of arthritis, osteoclast formation, and maintenance of bone mass
IE Adamopoulos, M Tessmer, CC Chao… - The Journal of …, 2011 - journals.aai.org
The role of IL-23 in the development of arthritis and bone metabolism was studied using
systemic IL-23 exposure in adult mice via hydrodynamic delivery of IL-23 minicircle DNA in …
systemic IL-23 exposure in adult mice via hydrodynamic delivery of IL-23 minicircle DNA in …
IL-17 targeted therapies for psoriasis
A Chiricozzi, JG Krueger - Expert opinion on investigational drugs, 2013 - Taylor & Francis
Introduction: Psoriasis is a chronic, disabling, inflammatory skin disease whose
pathogenesis still remains to be fully elucidated. Genetic and environmental factors induce …
pathogenesis still remains to be fully elucidated. Genetic and environmental factors induce …