Flavonoids are natural polyphenolic compounds which are included in a panoply of drugs
and used to treat and/or manage human ailments such as metabolic, cardiovascular …

Abstract Interleukin-11 (IL-11) is a cytokine that has been strongly implicated in the
pathogenesis of fibrotic diseases and solid malignancies. Elevated IL-11 expression is also …

Objective To evaluate the effect of secukinumab, an interleukin-17A inhibitor, on clinical
signs and symptoms and radiographic changes through 2 years in patients with ankylosing …

Objective To evaluate ixekizumab, an anti–interleukin‐17A (anti–IL‐17A) monoclonal
antibody, in 2 populations of rheumatoid arthritis (RA) patients: biologics‐naive patients and …

Bone remodeling is a lifelong process in vertebrates that relies on the correct balance
between bone resorption by osteoclasts and bone formation by osteoblasts. Bone loss and …

Bone homeostasis, which involves formation and resorption, is an important process for
maintaining adequate bone mass in humans. Rheumatoid arthritis (RA) is an autoimmune …

This study determined the effect of type 17 helper T-cell (Th17) cytokines on
osteoclastogenesis in rheumatoid arthritis (RA). The expression of IL-17 and receptor …

Quercetin (QU) has been shown obvious anti-arthritic property in pre-clinical studies or
clinical studies. Howbeit, the underlying mechanism of it is still not revealed distinctly and …

The role of IL-23 in the development of arthritis and bone metabolism was studied using
systemic IL-23 exposure in adult mice via hydrodynamic delivery of IL-23 minicircle DNA in …

Introduction: Psoriasis is a chronic, disabling, inflammatory skin disease whose
pathogenesis still remains to be fully elucidated. Genetic and environmental factors induce …