Update on the Pathogenesis of Chronic Obstructive Pulmonary Disease | New England Journal of
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The current epidemic of chronic obstructive pulmonary disease (COPD) has produced a
worldwide health care burden, approaching that imposed by transmittable infectious …

The current paradigm for the pathogenesis of chronic obstructive pulmonary disease is that
chronic airflow limitation results from an abnormal inflammatory response to inhaled …

The mechanisms involved in the genesis of chronic obstructive pulmonary disease (COPD)
are poorly defined. This area is complicated and difficult to model because COPD consists of …

Alveolar cell apoptosis is involved in the pathogenesis of emphysema, a prevalent disease
primarily caused by cigarette smoking. We report that ceramide, a second messenger lipid …

Vascular endothelial growth factor (VEGF) is a pluripotent growth and permeability factor
that has a broad impact on endothelial cell function. The lung tissue is very rich in this …

Cigarette smoke-induced animal models of chronic obstructive pulmonary disease support
the protease-antiprotease hypothesis of emphysema, although which cells and proteases …

α-1 Antitrypsin (A1AT) is an abundant circulating serpin with a postulated function in the lung
of potently inhibiting neutrophil-derived proteases. Emphysema attributable to A1AT …

As cells undergo apoptosis, they are recognized and removed from the body by phagocytes.
This oft-overlooked yet critical final step in the cell-death programme protects tissues from …

Rtp801 (also known as Redd1, and encoded by Ddit4), a stress-related protein triggered by
adverse environmental conditions, inhibits mammalian target of rapamycin (mTOR) by …