Tendinopathy

NL Millar, KG Silbernagel, K Thorborg… - Nature reviews Disease …, 2021 - nature.com
Tendinopathy describes a complex multifaceted pathology of the tendon, characterized by
pain, decline in function and reduced exercise tolerance. The most common overuse …

[HTML][HTML] Cytokines in inflammatory disease

S Kany, JT Vollrath, B Relja - International journal of molecular sciences, 2019 - mdpi.com
This review aims to briefly discuss a short list of a broad variety of inflammatory cytokines.
Numerous studies have implicated that inflammatory cytokines exert important effects with …

[HTML][HTML] Interleukin-18 in health and disease

K Yasuda, K Nakanishi, H Tsutsui - International journal of molecular …, 2019 - mdpi.com
Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from
anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag …

Interleukin‐33 (IL‐33): a nuclear cytokine from the IL‐1 family

C Cayrol, JP Girard - Immunological reviews, 2018 - Wiley Online Library
Summary Interleukin‐33 (IL‐33) is a tissue‐derived nuclear cytokine from the IL‐1 family
abundantly expressed in endothelial cells, epithelial cells and fibroblast‐like cells, both …

[HTML][HTML] Epithelial cell–derived cytokines: more than just signaling the alarm

F Roan, K Obata-Ninomiya… - The Journal of clinical …, 2019 - Am Soc Clin Investig
The epithelial cell–derived cytokines thymic stromal lymphopoietin (TSLP), IL-33, and IL-25
are central regulators of type 2 immunity, which drives a broad array of allergic responses …

Interleukin-33 in health and disease

FY Liew, JP Girard, HR Turnquist - Nature Reviews Immunology, 2016 - nature.com
Abstract Interleukin-33 (IL-33)—a member of the IL-1 family—was originally described as an
inducer of type 2 immune responses, activating T helper 2 (TH2) cells and mast cells. Now …

Tumor-initiating cells establish an IL-33–TGF-β niche signaling loop to promote cancer progression

S Taniguchi, A Elhance, A Van Duzer, S Kumar… - Science, 2020 - science.org
INTRODUCTION A small subset of tumor cells with long-term tumorigenic capacity, known
as tumor-initiating cells (TICs), play a pivotal role in cancer development and therapy …

Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion

W Chen, S Chen, C Yan, Y Zhang, R Zhang… - Nature …, 2022 - nature.com
Abstract Interleukin-33 (IL-33), an epithelial cell-derived cytokine that responds rapidly to
environmental insult, has a critical role in initiating airway inflammatory diseases. However …

Emerging functions of IL-33 in homeostasis and immunity

GK Dwyer, LM D'Cruz… - Annual review of …, 2022 - annualreviews.org
Our understanding of the functions of the IL-1 superfamily cytokine and damage-associated
molecular pattern IL-33 continues to evolve with our understanding of homeostasis and …

[PDF][PDF] Interleukin-33 in tissue homeostasis, injury, and inflammation

AB Molofsky, AK Savage, RM Locksley - Immunity, 2015 - cell.com
Interleukin-33 (IL-33) is a nuclear-associated cytokine of the IL-1 family originally described
as a potent inducer of allergic type 2 immunity. IL-33 signals via the receptor ST2, which is …