Increased glucose metabolism and uptake are characteristic of many tumors and used
clinically to diagnose and monitor cancer progression. In addition to cancer cells, the tumor …

CD8+ T cells are end effectors of cancer immunity. Most forms of effective cancer
immunotherapy involve CD8+ T cell effector function. Here, we review the current …

Metabolic pathways and redox reactions are at the core of life. In the past decade (s),
numerous discoveries have shed light on how metabolic pathways determine the cellular …

The growing field of immune metabolism has revealed promising indications for metabolic
targets to modulate anti-cancer immunity. Combination therapies involving metabolic …

Adaptive immune responses mediated by T cells and B cells are crucial for protective
immunity against pathogens and tumors. Differentiation and function of immune cells require …

Naive T cells are actively maintained in a quiescent state that promotes their survival and
persistence. On antigen stimulation, T cells exit quiescence to initiate clonal expansion and …

Immune cells' metabolism influences their differentiation and function. Given that a complex
interplay of environmental factors within the tumor microenvironment (TME) can have a …

T cells orchestrate adaptive immunity against pathogens and other immune challenges, but
their dysfunction can also mediate the pathogenesis of cancer and autoimmunity. Metabolic …

The development of immunotherapies over the past decade has resulted in a paradigm shift
in the treatment of cancer. However, the majority of patients do not benefit from …

Vaccination affords protection from disease by activating pathogen-specific immune cells
and facilitating the development of persistent immunologic memory toward the vaccine …