Discovered more than 30 years ago, the angiotensin AT2 receptor (AT2R) has evolved from
a binding site with unknown function to a firmly established major effector within the …

Liver fibrosis is the excessive accumulation of extracellular matrix proteins including
collagen that occurs in most types of chronic liver diseases. Advanced liver fibrosis results in …

Angiotensin II (Ang II) is a pro-oxidant and fibrogenic cytokine. We investigated the role of
NADPH oxidase in Ang II–induced effects in hepatic stellate cells (HSCs), a fibrogenic cell …

Background: Angiotensin converting enzyme (ACE) 2 is a recently identified homologue of
ACE that may counterregulate the actions of angiotensin (Ang) II by facilitating its breakdown …

The liver is a crucial metabolic organ that has a key role in maintaining immune and
endocrine homeostasis. Accumulating evidence suggests that chronic liver disease might …

Abstract Purpose of the Review This review aims to summarize the current knowledge of the
extracellular matrix remodeling during hepatic fibrosis. We discuss the diverse interactions …

Significance: Hepatic fibrosis is the common pathophysiologic process resulting from
chronic liver injury, characterized by the accumulation of an excessive extracellular matrix …

Portal hypertension and bleeding from gastroesophageal varices is the major cause of
morbidity and mortality in patients with cirrhosis. Portal hypertension is initiated by increased …

The renin–angiotensin system (RAS) is usually associated with its systemic action on
cardiovascular homoeostasis. However, recent studies suggest that at a local tissue level …

▪ Abstract Liver fibrosis is the common response to chronic liver injury, ultimately leading to
cirrhosis and its complications, portal hypertension, liver failure, and hepatocellular …