Highlights•Engineering parameters of most common single-use bioreactor designs are
provided.•Scale up and down between the μL to the m 3 range is discussed.•Impacts on …

Euler‐Lagrange CFD simulations, where the biotic phase is represented by computational
particles (parcels), provide information on environmental gradients inside bioreactors from …

The development of new biopharmaceuticals relies on robust scale-up from small-scale
screening studies to industrial bioreactors. Novel SUB designs can prove highly beneficial …

HEK293 is a widely used cell line in the fields of research and industry. It is assumed that
these cells are sensitive to hydrodynamic stress. The aim of this research was to use particle …

Laboratory-scale bioreactors represent an important part of microbiological,
biotechnological, and biochemical researches. The small volume bioreactors enable the …

A novel single‐use bioreactor was recently introduced to the market that is agitated by
impellers suspended on flexible ropes rather than a rigid shaft. Computational fluid …

The impact of specific power input on gas-liquid mass transfer and mixing has not been
extensively reported for rocking disposable bioreactors. An electrical method was applied for …

The power input in stirred bioreactors is an important scaling-up parameter and can be
measured through the torque that acts on the impeller shaft during rotation. However, the …

Microcarrier suspension performance and ensemble-averaged flow fields at the just-
suspended condition are studied in a scale-down mimic of the Allegro STR single-use …

Background Power-to-gas is the pivotal link between electricity and gas infrastructure,
enabling the broader integration of renewable energy. Yet, enhancements are necessary for …