Abstract Therapy-Induced Senescence (TIS) is an established response to anticancer
therapy in a variety of cancer models. Ample evidence has characterized the triggers …

Melanoma, the deadliest form of skin cancer, poses a significant clinical challenge for the
development of effective treatments. Conventional in vivo animal studies have shown limited …

Malignant melanoma (MM) is the most metastatic and aggressive form of skin cancer, and
carries a high risk of death. Immune-checkpoint inhibitor therapy and molecular-targeted …

Hippomarathrum scabrum L. is an endemic medicinal plant in Turkey; however, there have
been few studies investigating the phytochemistry and biological properties of these plants …

Diffuse-type gastric cancer (DGC) is a subtype of gastric cancer with aggressiveness and
poor prognosis. It is of great significance to find sensitive drugs for DGC. In the current study …

The extent to which transcription factors read and respond to specific information content
within short DNA sequences remains an important question that the tumor suppressor p53 is …

EGFR-mutant lung adenocarcinoma (LUAD) mostly depends on EGFR for survival and
consequently responds well to EGFR inhibitors. However, resistance to the drugs develops …

Anti-cancer therapies may induce proliferative arrest in cancer cells in the form of
senescence or drug-tolerant persistency, the latter being a reversible arrest with similarities …

Colorectal cancer, recognized as a quintessential age-related disease, underscores the
intricate interplay between aging mechanisms and disease pathogenesis. Cellular …

TTK (MPS1) spindle assembly checkpoint kinase is an emerging cancer target. This
preclinical study explored the anti-tumor mechanism of TTK inhibitor OSU13 to define a …