Therapy-induced senescence as a component of tumor biology: Evidence from clinical cancer
T Saleh, S Bloukh, M Hasan, S Al Shboul - Biochimica et Biophysica Acta …, 2023 - Elsevier
Abstract Therapy-Induced Senescence (TIS) is an established response to anticancer
therapy in a variety of cancer models. Ample evidence has characterized the triggers …
therapy in a variety of cancer models. Ample evidence has characterized the triggers …
[HTML][HTML] Bridging the gap between testing and clinics exploring alternative pre-clinical models in melanoma research
J Viegas, B Sarmento - Advanced Drug Delivery Reviews, 2024 - Elsevier
Melanoma, the deadliest form of skin cancer, poses a significant clinical challenge for the
development of effective treatments. Conventional in vivo animal studies have shown limited …
development of effective treatments. Conventional in vivo animal studies have shown limited …
[HTML][HTML] Role of the tumor microenvironment in malignant melanoma organoids during the development and metastasis of tumors
S Zhou, J Lu, S Liu, J Shao, Z Liu, J Li… - Frontiers in Cell and …, 2023 - frontiersin.org
Malignant melanoma (MM) is the most metastatic and aggressive form of skin cancer, and
carries a high risk of death. Immune-checkpoint inhibitor therapy and molecular-targeted …
carries a high risk of death. Immune-checkpoint inhibitor therapy and molecular-targeted …
Extractions of aerial parts of Hippomarathrum scabrum with conventional and green methodologies: Chemical profiling, antioxidant, enzyme inhibition, and anti …
Hippomarathrum scabrum L. is an endemic medicinal plant in Turkey; however, there have
been few studies investigating the phytochemistry and biological properties of these plants …
been few studies investigating the phytochemistry and biological properties of these plants …
[HTML][HTML] Drug-induced senescence by aurora kinase inhibitors attenuates innate immune response of macrophages on gastric cancer organoids
R Yang, W Kwan, Y Du, R Yan, L Zang, C Li, Z Zhu… - Cancer Letters, 2024 - Elsevier
Diffuse-type gastric cancer (DGC) is a subtype of gastric cancer with aggressiveness and
poor prognosis. It is of great significance to find sensitive drugs for DGC. In the current study …
poor prognosis. It is of great significance to find sensitive drugs for DGC. In the current study …
[HTML][HTML] Determinants of p53 DNA binding, gene regulation, and cell fate decisions
M Fischer, MA Sammons - Cell Death & Differentiation, 2024 - nature.com
The extent to which transcription factors read and respond to specific information content
within short DNA sequences remains an important question that the tumor suppressor p53 is …
within short DNA sequences remains an important question that the tumor suppressor p53 is …
[HTML][HTML] Dual inhibition of KIF11 and BCL2L1 induces apoptosis in lung adenocarcinoma cells
Y Sakuma, S Hirai, T Sumi, T Niki… - … and Biophysical Research …, 2023 - Elsevier
EGFR-mutant lung adenocarcinoma (LUAD) mostly depends on EGFR for survival and
consequently responds well to EGFR inhibitors. However, resistance to the drugs develops …
consequently responds well to EGFR inhibitors. However, resistance to the drugs develops …
Persister cancer cells are characterized by H4K20me3 heterochromatin that defines a low inflammatory profile
V Ramponi, L Richart, M Kovatcheva… - bioRxiv, 2024 - biorxiv.org
Anti-cancer therapies may induce proliferative arrest in cancer cells in the form of
senescence or drug-tolerant persistency, the latter being a reversible arrest with similarities …
senescence or drug-tolerant persistency, the latter being a reversible arrest with similarities …
[HTML][HTML] Prognostic significance of a signature based on senescence-related genes in colorectal cancer
Colorectal cancer, recognized as a quintessential age-related disease, underscores the
intricate interplay between aging mechanisms and disease pathogenesis. Cellular …
intricate interplay between aging mechanisms and disease pathogenesis. Cellular …
TTK inhibitor OSU13 promotes immunotherapy responses by activating tumor STING
TTK (MPS1) spindle assembly checkpoint kinase is an emerging cancer target. This
preclinical study explored the anti-tumor mechanism of TTK inhibitor OSU13 to define a …
preclinical study explored the anti-tumor mechanism of TTK inhibitor OSU13 to define a …