Regulation of mitogen-activated protein kinase signaling pathways by the ubiquitin-proteasome system and its pharmacological potential
S Mathien, C Tesnière, S Meloche… - Pharmacological …, 2021 - Elsevier
Mitogen-activated protein kinase (MAPK) cascades are evolutionarily conserved signaling
pathways that play essential roles in transducing extracellular environmental signals into …
pathways that play essential roles in transducing extracellular environmental signals into …
An axonal stress response pathway: degenerative and regenerative signaling by DLK
Highlights•DLK is an evolutionarily conserved sensor of axonal damage and cytoskeletal
stress.•DLK coordinates both regenerative and degenerative responses to axonal …
stress.•DLK coordinates both regenerative and degenerative responses to axonal …
Loss-of-function variants in MYCBP2 cause neurobehavioural phenotypes and corpus callosum defects
L AlAbdi, M Desbois, DV Rusnac, RA Sulaiman… - Brain, 2023 - academic.oup.com
The corpus callosum is a bundle of axon fibres that connects the two hemispheres of the
brain. Neurodevelopmental disorders that feature dysgenesis of the corpus callosum as a …
brain. Neurodevelopmental disorders that feature dysgenesis of the corpus callosum as a …
[HTML][HTML] Single-cell type analysis of wing premotor circuits in the ventral nerve cord of Drosophila melanogaster
To perform most behaviors, animals must send commands from higher-order processing
centers in the brain to premotor circuits that reside in ganglia distinct from the brain, such as …
centers in the brain to premotor circuits that reside in ganglia distinct from the brain, such as …
PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2
PHR (PAM/Highwire/RPM-1) proteins are conserved RING E3 ubiquitin ligases that function
in developmental processes, such as axon termination and synapse formation, as well as …
in developmental processes, such as axon termination and synapse formation, as well as …
Spatiotemporal Control of Neuronal Remodeling by Cell Adhesion Molecules: Insights From Drosophila
H Meltzer, O Schuldiner - Frontiers in neuroscience, 2022 - frontiersin.org
Developmental neuronal remodeling is required for shaping the precise connectivity of the
mature nervous system. Remodeling involves pruning of exuberant neural connections …
mature nervous system. Remodeling involves pruning of exuberant neural connections …
RPM-1 regulates axon termination by affecting growth cone collapse and microtubule stability
MA Borgen, D Wang, B Grill - Development, 2017 - journals.biologists.com
Axon termination is essential for efficient and accurate nervous system construction. At
present, relatively little is known about how growth cone collapse occurs prior to axon …
present, relatively little is known about how growth cone collapse occurs prior to axon …
Regulation of subcellular dendritic synapse specificity by axon guidance cues
Neural circuit assembly occurs with subcellular precision, yet the mechanisms underlying
this precision remain largely unknown. Subcellular synaptic specificity could be achieved by …
this precision remain largely unknown. Subcellular synaptic specificity could be achieved by …
The equilibrium between antagonistic signaling pathways determines the number of synapses in Drosophila
S Jordan-Alvarez, E Santana, S Casas-Tinto… - PLoS …, 2017 - journals.plos.org
The number of synapses is a major determinant of behavior and many neural diseases
exhibit deviations in that number. However, how signaling pathways control this number is …
exhibit deviations in that number. However, how signaling pathways control this number is …
A MIG-15/JNK-1 MAP kinase cascade opposes RPM-1 signaling in synapse formation and learning
The Pam/Highwire/RPM-1 (PHR) proteins are conserved intracellular signaling hubs that
regulate synapse formation and axon termination. The C. elegans PHR protein, called RPM …
regulate synapse formation and axon termination. The C. elegans PHR protein, called RPM …