Over the last 2 decades, a large number of neurophysiological and neuroimaging studies of
patients with schizophrenia have furnished in vivo evidence for dysconnectivity, ie, abnormal …

Schizophrenia is a serious mental disorder that affects up to 1% of the population worldwide.
As of yet, neurochemical mechanisms underlying schizophrenia remain unknown. To date …

In an effort to pinpoint potential genetic risk factors for schizophrenia, research groups
worldwide have published over 1,000 genetic association studies with largely inconsistent …

MicroRNAs (miRNAs) are a large family of small non-coding RNAs which negatively control
gene expression at both the mRNA and protein levels. The number of miRNAs identified is …

NMDA receptors (NMDARs) are glutamate-gated cation channels with high calcium
permeability that play important roles in many aspects of the biology of higher organisms …

Many aspects of synaptic development, plasticity, and neurotransmission are critically
influenced by NMDAtype glutamate receptors (NMDARs). Moreover, dysfunction of …

Huntington's disease is an autosomal dominant disorder caused by a mutation in the gene
encoding the protein huntingtin on chromosome 4. The mutation is an expanded CAG …

In the era of greatly improved pharmacological treatment of HIV infection through highly
active antiretroviral therapy (HAART), HIV patients experience reduced viral loads, reduced …

Altered glutamatergic and dopaminergic signaling has been proposed as contributing to the
specific striatal cell death observed in Huntington's disease (HD). However, the precise …

Although levodopa remains the most effective drug for the symptomatic treatment of
Parkinson's disease, chronic therapy with this pharmacological compound initiates a …