Synaptic specificity, recognition molecules, and assembly of neural circuits

JR Sanes, SL Zipursky - Cell, 2020 - cell.com
Developing neurons connect in specific and stereotyped ways to form the complex circuits
that underlie brain function. By comparison to earlier steps in neural development, progress …

Specification of synaptic connectivity by cell surface interactions

J De Wit, A Ghosh - Nature Reviews Neuroscience, 2016 - nature.com
The molecular diversification of cell surface molecules has long been postulated to impart
specific surface identities on neuronal cell types. The existence of unique cell surface …

Sour sensing from the tongue to the brain

J Zhang, H Jin, W Zhang, C Ding, S O'Keeffe, M Ye… - Cell, 2019 - cell.com
The ability to sense sour provides an important sensory signal to prevent the ingestion of
unripe, spoiled, or fermented foods. Taste and somatosensory receptors in the oral cavity …

Regulation of neural circuit formation by protocadherins

SL Peek, KM Mah, JA Weiner - Cellular and molecular life sciences, 2017 - Springer
The protocadherins (Pcdhs), which make up the most diverse group within the cadherin
superfamily, were first discovered in the early 1990s. Data implicating the Pcdhs, including …

Synapse development and maturation at the drosophila neuromuscular junction

VT Chou, SA Johnson, D Van Vactor - Neural development, 2020 - Springer
Synapses are the sites of neuron-to-neuron communication and form the basis of the neural
circuits that underlie all animal cognition and behavior. Chemical synapses are specialized …

A subset of autism-associated genes regulate the structural stability of neurons

YC Lin, JA Frei, MBC Kilander, W Shen… - Frontiers in cellular …, 2016 - frontiersin.org
Autism spectrum disorder (ASD) comprises a range of neurological conditions that affect
individuals' ability to communicate and interact with others. People with ASD often exhibit …

Nitric Oxide-Scavenging, Anti-Migration Effects, and Glycosylation Changes after Hemin Treatment of Human Triple-Negative Breast Cancer Cells: A Mechanistic …

AM Alsharabasy, A Aljaabary, R Bohara… - ACS Pharmacology & …, 2023 - ACS Publications
The enhanced expression of nitric oxide (• NO) synthase predicts triple-negative breast
cancer outcome and its resistance to different therapeutics. Our earlier work demonstrated …

CDH2 mutation affecting N-cadherin function causes attention-deficit hyperactivity disorder in humans and mice

D Halperin, A Stavsky, R Kadir, M Drabkin… - Nature …, 2021 - nature.com
Attention-deficit hyperactivity disorder (ADHD) is a common childhood-onset psychiatric
disorder characterized by inattention, impulsivity and hyperactivity. ADHD exhibits …

Flying under the radar: CDH2 (N-cadherin), an important hub molecule in neurodevelopmental and neurodegenerative diseases

ZI László, Z Lele - Frontiers in Neuroscience, 2022 - frontiersin.org
CDH2 belongs to the classic cadherin family of Ca2+-dependent cell adhesion molecules
with a meticulously described dual role in cell adhesion and β-catenin signaling. During …

Coordinated cadherin functions sculpt respiratory motor circuit connectivity

AN Vagnozzi, MT Moore, M Lin, EM Brozost, KC Ritesh… - Elife, 2022 - elifesciences.org
Breathing, and the motor circuits that control it, is essential for life. At the core of respiratory
circuits are Dbx1-derived interneurons, which generate the rhythm and pattern of breathing …