Encoded in mammalian cells by 33 genes, the transforming growth factor–β (TGF-β) family
of secreted, homodimeric and heterodimeric proteins controls the differentiation of most, if …

Transforming growth factor β (TGF-β) plays an important role in normal development and
homeostasis. Dysregulation of TGF-β responsiveness and its downstream signaling …

Galectin-3 is a versatile protein orchestrating several physiological and pathophysiological
processes in the human body. In the last decade, considerable interest in galectin-3 has …

Transforming growth factor (TGF)-β family proteins control cell physiology, proliferation, and
growth, and direct cell differentiation, thus playing key roles in normal development and …

Inhibitors of the ALK and EGF receptor tyrosine kinases provoke dramatic but short-lived
responses in lung cancers harboring EML4-ALK translocations or activating mutations of …

The raised considerable concerns about the possible environmental health and safety
impacts of graphene nanomaterials and their derivatives originated from their potential …

Background Core fucosylation (addition of fucose in α-1, 6-linkage to core N-
acetylglucosamine of N-glycans) catalyzed by fucosyltransferase 8 (FUT8) is critical for …

Background Peroxisome proliferator-activated receptor gamma (PPARγ) is an enhancer of
Treg responses, but the mechanisms remain elusive. This study aimed to solve this problem …

Glycosylation is a very frequent and functionally important post-translational protein
modification that undergoes profound changes in cancer. Growth and death factor receptors …

Background Radiotherapy is a conventional and effective local treatment for breast cancer.
However, residual or recurrent tumors appears frequently because of radioresistance. Novel …