Three-dimensional (3D) bioprinting has emerged to create novel cell-based therapies for
regenerative medicine applications. Vascularized networks within engineered constructs are …

The ECM (extracellular matrix) is a 3-dimensional network that supports cellular responses
and maintains structural tissue integrity in healthy and pathological conditions. The …

The formation of functional capillary blood vessels that can sustain the metabolic demands
of transplanted parenchymal cells remains one of the biggest challenges to the clinical …

Despite serving as the clinical “gold standard” treatment for critical size bone defects,
decellularized allografts suffer from long-term failure rates of~ 60% due to the absence of the …

In recent years, biologists and clinicians have witnessed prominent advances in in vitro 3D
culture techniques related to biomimetic human/animal tissue analogs. Numerous data have …

Purpose Correctly identifying nodal status is recognized as a critical prognostic factor in
many cancer types and is essential to guide adjuvant treatment. Currently, surgical removal …

Biomaterials can be intentionally designed to support and even guide vascularization for
applications ranging from engineered organs to treatment of ischemic diseases like …

Gradients in mechanical properties, physical architecture and biochemical composition exist
in a variety of complex tissues, yet 3D in vitro models that enable investigation of these cues …

Binding kinetics play an important role in cancer diagnosis and therapeutics. However,
current methods of quantifying binding kinetics fail to consider the three-dimensional …

Biomaterials are pivotal in supporting and guiding vascularization for therapeutic
applications. To design effective, bioactive biomaterials, understanding the cellular and …