Correlates of protection (CoPs) are increasingly important in the development and licensure
of vaccines. Although the study of CoPs was initially directed at identifying a single immune …

Highlights•Early viral infections shape B cell response recalled against future viral
strains.•Competition between memory and naïve B cells occurs in secondary viral …

Predictive models of immune protection from COVID-19 are urgently needed to identify
correlates of protection to assist in the future deployment of vaccines. To address this, we …

Background We evaluated safety and immunogenicity of the first mRNA vaccines against
potentially pandemic avian H10N8 and H7N9 influenza viruses. Methods Two randomized …

Background: Influenza infects 5–15% of the global population each year, and obesity has
been shown to be an independent risk factor for increased influenza-related complications …

Despite long-term investment, influenza continues to be a significant worldwide problem.
The cornerstone of protection remains vaccination, and approved vaccines seek to elicit a …

We introduce the antibody landscape, a method for the quantitative analysis of antibody-
mediated immunity to antigenically variable pathogens, achieved by accounting for …

Influenza viruses remain a severe threat to human health, causing up to 650,000 deaths
annually,. Seasonal influenza virus vaccines can prevent infection, but are rendered …

Background. Influenza-related morbidity and mortality remain high. Seasonal vaccination is
the backbone of influenza management but does not always result in protective antibody …

Correlates of protection are key for vaccine development against any pathogen. In this paper
we summarize recent information about correlates for vaccines against dengue, Ebola …