Forensic biochemistry for functional investigation of death: concept and practical application

H Maeda, T Ishikawa, T Michiue - Legal Medicine, 2011 - Elsevier
The essential tasks of forensic pathology involve investigation of the cause and process of
death, especially in traumatic and unexpected sudden deaths, largely including …

Heart-type fatty acid-binding protein in cardiovascular disease: A systemic review

Y Otaki, T Watanabe, I Kubota - Clinica chimica acta, 2017 - Elsevier
Fatty acid-binding proteins, whose clinical applications have been studied, are a family of
proteins that reflect tissue injury. Heart-type fatty acid-binding protein (H-FABP) is a marker …

Heart-type fatty acid-binding protein predicts long-term mortality and re-infarction in consecutive patients with suspected acute coronary syndrome who are troponin …

K Viswanathan, N Kilcullen, C Morrell… - Journal of the American …, 2010 - jacc.org
Objectives: The purpose of this study was to establish the prognostic value of measuring
heart fatty acid-binding protein (H-FABP) in patients with suspected acute coronary …

Heart-type fatty acid-binding protein predicts long-term mortality after acute coronary syndrome and identifies high-risk patients across the range of troponin values

N Kilcullen, K Viswanathan, R Das, C Morrell… - Journal of the American …, 2007 - jacc.org
Objectives: Our aim was to determine if a high-performance assay for heart-type fatty acid-
binding protein (H-FABP) has a role in predicting all-cause mortality after acute coronary …

Molecular tissue changes in early myocardial ischemia: from pathophysiology to the identification of new diagnostic markers

A Aljakna, T Fracasso, S Sabatasso - International journal of legal …, 2018 - Springer
Diagnosing early myocardial ischemia (the initial 4 to 6 h after interruption of blood flow to
part of the myocardium) remains a challenge for clinical and forensic pathologists. Several …

Chronic drug‐induced effects on contractile motion properties and cardiac biomarkers in human induced pluripotent stem cell‐derived cardiomyocytes

I Kopljar, A De Bondt, P Vinken… - British journal of …, 2017 - Wiley Online Library
Background and Purpose In the pharmaceutical industry risk assessments of chronic cardiac
safety liabilities are mostly performed during late stages of preclinical drug development …

[图书][B] Toxicologic pathology: nonclinical safety assessment

PS Sahota, JA Popp, JF Hardisty, C Gopinath - 2013 - books.google.com
As drug development shifts over time to address unmet medical needs and more targeted
therapies are developed, previously unseen pharmacological or off-target effects may occur …

Time course characterization of serum cardiac troponins, heart fatty acid–binding protein, and morphologic findings with isoproterenol-induced myocardial injury in the …

P Clements, S Brady, M York, B Berridge… - Toxicologic …, 2010 - journals.sagepub.com
We investigated the kinetics of circulating biomarker elevation, specifically correlated with
morphology in acute myocardial injury. Male Hanover Wistar rats underwent biomarker and …

[HTML][HTML] Association of heart-type fatty acid-binding protein with cardiovascular risk factors and all-cause mortality in the general population: the Takahata study

Y Otaki, T Watanabe, H Takahashi, A Hirayama… - PloS one, 2014 - journals.plos.org
Background Despite many recent advances in medicine, preventing the development of
cardiovascular diseases remains a challenge. Heart-type fatty acid-binding protein (H …

Sorbin and SH 3 Domain‐Containing Protein 2 Is Released From Infarcted Heart in the Very Early Phase: Proteomic Analysis of Cardiac Tissues From Patients

Y Kakimoto, S Ito, H Abiru, H Kotani… - Journal of the …, 2013 - Am Heart Assoc
Background Few proteomic studies have examined human cardiac tissue following acute
lethal infarction. Here, we applied a novel proteomic approach to formalin‐fixed, paraffin …