Citrate is a key metabolite of the Krebs cycle that can also be exported in the cytosol, where
it performs several functions. In normal cells, citrate sustains protein acetylation, lipid …

Tricarboxylic acid (TCA) cycle, also called Krebs cycle or citric acid cycle, is an amphoteric
pathway, contributing to catabolic degradation and anaplerotic reactions to supply …

Background Synovial fibroblasts in rheumatoid arthritis (RAFLS) exhibit a pathological
aberration of glycolysis and glutaminolysis. Henceforth, we aimed to investigate if dual …

Abstract Background Enolase 2 (ENO2) is a crucial glycolytic enzyme in cancer metabolic
process and acts as a “moonlighting” protein to play various functions in diverse cellular …

Background Targeting mitochondrial oncoproteins presents a new concept in the
development of effective cancer therapeutics. ATAD3A is a nuclear-encoded mitochondrial …

Approximately 70% of human breast cancers express estrogen receptor-α (ERα), providing
a potential target for endocrine therapy. However, 30% to 40% of patients with ER+ breast …

Metabolic abnormalities are an important feature of tumours. The glutamine-arginine-proline
axis is an important node of cancer metabolism and plays a major role in amino acid …

Head and neck squamous cell carcinoma (HNSCC) is among the most prevalent cancer
worldwide, with the most severe impact on quality of life of patients. Despite the …

Oral squamous cell carcinoma (OSCC) accounts for around 90% of all oral cancers and is
the eighth most common cancer worldwide. Despite progress in managing OSCC, the …

Glycolytic metabolism may account for antitumor immunity failure. Pyruvate kinase M2
(PKM2) and platelet phosphofructokinase (PFKP), two key enzymes involved in the …