Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease
N Guzior, A Wieckowska, D Panek… - Current medicinal …, 2015 - ingentaconnect.com
Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder. The
available therapy is limited to the symptomatic treatment and its efficacy remains …
available therapy is limited to the symptomatic treatment and its efficacy remains …
Quinones as neuroprotective agents
Á Cores, N Carmona-Zafra, J Clerigué, M Villacampa… - Antioxidants, 2023 - mdpi.com
Quinones can in principle be viewed as a double-edged sword in the treatment of
neurodegenerative diseases, since they are often cytoprotective but can also be cytotoxic …
neurodegenerative diseases, since they are often cytoprotective but can also be cytotoxic …
Controlling compartmentalization by non-membrane-bound organelles
RJ Wheeler, AA Hyman - Philosophical Transactions of …, 2018 - royalsocietypublishing.org
Compartmentalization is a characterizing feature of complexity in cells, used to organize
their biochemistry. Membrane-bound organelles are most widely known, but non-membrane …
their biochemistry. Membrane-bound organelles are most widely known, but non-membrane …
Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation
Y Feng, X Wang, S Yang, Y Wang, X Zhang, X Du… - Neurotoxicology, 2009 - Elsevier
Beta-amyloid (Aβ) aggregation has been strongly associated with the neurodegenerative
pathology and a cascade of harmful event rated to Alzheimer's disease (AD). Inhibition of Aβ …
pathology and a cascade of harmful event rated to Alzheimer's disease (AD). Inhibition of Aβ …
Rutin inhibits β-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines
S Wang, YJ Wang, Y Su, W Zhou, S Yang, R Zhang… - Neurotoxicology, 2012 - Elsevier
Alzheimer's disease (AD) is a complex, multi-factorial neurodegenerative disease. The
aggregation of soluble β-amyloid (Aβ) into fibrillar deposits is a pathological hallmark of AD …
aggregation of soluble β-amyloid (Aβ) into fibrillar deposits is a pathological hallmark of AD …
Journey on naphthoquinone and anthraquinone derivatives: new insights in Alzheimer's disease
M Campora, V Francesconi, S Schenone, B Tasso… - Pharmaceuticals, 2021 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease that is characterized
by memory loss, cognitive impairment, and functional decline leading to dementia and …
by memory loss, cognitive impairment, and functional decline leading to dementia and …
Effects of several quinones on insulin aggregation
H Gong, Z He, A Peng, X Zhang, B Cheng, Y Sun… - Scientific reports, 2014 - nature.com
Protein misfolding and aggregation are associated with more than twenty diseases, such as
neurodegenerative diseases and metabolic diseases. The amyloid oligomers and fibrils may …
neurodegenerative diseases and metabolic diseases. The amyloid oligomers and fibrils may …
Destabilizing Alzheimer's Aβ42 Protofibrils with Morin: Mechanistic Insights from Molecular Dynamics Simulations
Alzheimer's disease is a progressive, neurodegenerative disorder that is the leading cause
of senile dementia, afflicting millions of individuals worldwide. Since the identification of the …
of senile dementia, afflicting millions of individuals worldwide. Since the identification of the …
On the role of synthesized hydroxylated chalcones as dual functional amyloid-β aggregation and ferroptosis inhibitors for potential treatment of Alzheimer's disease
In addition to amyloid cascade hypothesis, ferroptosis–a recently identified cell death
pathway associated with the accumulation of lipid hydroperoxides–was hypothesized as …
pathway associated with the accumulation of lipid hydroperoxides–was hypothesized as …
Insight into amyloid structure using chemical probes
AA Reinke, JE Gestwicki - Chemical biology & drug design, 2011 - Wiley Online Library
Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by the
deposition of amyloids in the brain. One prominent form of amyloid is composed of repeating …
deposition of amyloids in the brain. One prominent form of amyloid is composed of repeating …