Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease

N Guzior, A Wieckowska, D Panek… - Current medicinal …, 2015 - ingentaconnect.com
Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder. The
available therapy is limited to the symptomatic treatment and its efficacy remains …

Quinones as neuroprotective agents

Á Cores, N Carmona-Zafra, J Clerigué, M Villacampa… - Antioxidants, 2023 - mdpi.com
Quinones can in principle be viewed as a double-edged sword in the treatment of
neurodegenerative diseases, since they are often cytoprotective but can also be cytotoxic …

Controlling compartmentalization by non-membrane-bound organelles

RJ Wheeler, AA Hyman - Philosophical Transactions of …, 2018 - royalsocietypublishing.org
Compartmentalization is a characterizing feature of complexity in cells, used to organize
their biochemistry. Membrane-bound organelles are most widely known, but non-membrane …

Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation

Y Feng, X Wang, S Yang, Y Wang, X Zhang, X Du… - Neurotoxicology, 2009 - Elsevier
Beta-amyloid (Aβ) aggregation has been strongly associated with the neurodegenerative
pathology and a cascade of harmful event rated to Alzheimer's disease (AD). Inhibition of Aβ …

Rutin inhibits β-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines

S Wang, YJ Wang, Y Su, W Zhou, S Yang, R Zhang… - Neurotoxicology, 2012 - Elsevier
Alzheimer's disease (AD) is a complex, multi-factorial neurodegenerative disease. The
aggregation of soluble β-amyloid (Aβ) into fibrillar deposits is a pathological hallmark of AD …

Journey on naphthoquinone and anthraquinone derivatives: new insights in Alzheimer's disease

M Campora, V Francesconi, S Schenone, B Tasso… - Pharmaceuticals, 2021 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease that is characterized
by memory loss, cognitive impairment, and functional decline leading to dementia and …

Effects of several quinones on insulin aggregation

H Gong, Z He, A Peng, X Zhang, B Cheng, Y Sun… - Scientific reports, 2014 - nature.com
Protein misfolding and aggregation are associated with more than twenty diseases, such as
neurodegenerative diseases and metabolic diseases. The amyloid oligomers and fibrils may …

Destabilizing Alzheimer's Aβ42 Protofibrils with Morin: Mechanistic Insights from Molecular Dynamics Simulations

JA Lemkul, DR Bevan - Biochemistry, 2010 - ACS Publications
Alzheimer's disease is a progressive, neurodegenerative disorder that is the leading cause
of senile dementia, afflicting millions of individuals worldwide. Since the identification of the …

On the role of synthesized hydroxylated chalcones as dual functional amyloid-β aggregation and ferroptosis inhibitors for potential treatment of Alzheimer's disease

L Cong, X Dong, Y Wang, Y Deng, B Li, R Dai - European journal of …, 2019 - Elsevier
In addition to amyloid cascade hypothesis, ferroptosis–a recently identified cell death
pathway associated with the accumulation of lipid hydroperoxides–was hypothesized as …

Insight into amyloid structure using chemical probes

AA Reinke, JE Gestwicki - Chemical biology & drug design, 2011 - Wiley Online Library
Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by the
deposition of amyloids in the brain. One prominent form of amyloid is composed of repeating …