Neurophysiological experiments in primates, alongside neuropsychological and functional
magnetic resonance investigations in humans, have significantly enhanced our …

A large body of evidence supports the hypothesis that mesolimbic dopamine (DA) mediates,
in animal models, the reinforcing effects of central nervous system stimulants such as …

Establishing a function for the neuromodulator serotonin in human decision-making has
proved remarkably difficult because if its complex role in reward and punishment …

We developed a reproducible, simple, and small-scale method for determining the re-uptake
and release of monoamines (dopamine, serotonin (5-HT) and norepinephrine) using rat …

While accumulating evidence suggests that effective real-life decision-making depends
upon the functioning of the orbitofrontal cortex, much less is known about the involvement of …

The recent escalation of cocaine abuse has increased awareness of the need to understand
the behavioral effects of cocaine and the determinants of those effects. Cocaine alters both …

Cocaine conditioned place preference (CPP) is intact in dopamine transporter (DAT)
knockout (KO) mice and enhanced in serotonin transporter (SERT) KO mice. However …

The purpose of the present manuscript is to review the current status of the role of serotonin
(5-hydroxytryptamine; 5-HT) systems in the stimulus and reinforcing properties of cocaine in …

Acute behavioral responses to cocaine are more pronounced in female than in male rats.
We have shown that 3 weeks of treatment with 17β-estradiol (E2) implants significantly …

Nowadays, more and more young people want to experience illegal, psychoactive
substances, without knowing the risks of exposure. Besides affecting social life …