Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …

Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic
homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their …

The sarcomeric interaction of α-myosin heavy chain (α-MHC) with Titin is vital for cardiac
structure and contraction. However, the mechanism regulating this interaction in normal and …

In eukaryotic cells, DNA is tightly packed with the help of histone proteins into chromatin.
Chromatin architecture can be modified by various post‐translational modifications of …

Lysine succinylation is one of the major post-translational modifications occurring on
histones and is believed to have significant roles in regulating chromatin structure and …

The emergence of a nucleosome-based chromatin structure accompanied the evolutionary
transition from prokaryotes to eukaryotes. In this scenario, histones became the heart of the …

Post-translational modifications (PTMs) dynamically regulate cellular processes. Lysine
undergoes a range of acylations, including malonylation, succinylation (SucK) and …

Sirtiun 5 (SIRT5) is a NAD+-dependent protein lysine deacylase primarily located in
mitochondria. SIRT5 displays an affinity for negatively charged acyl groups and mainly …

Abstract p53 is a classic tumor suppressor that functions in maintaining genome stability by
inducing either cell arrest for damage repair or cell apoptosis to eliminate damaged cells in …

Lysine lactylation (Kla) links metabolism and gene regulation and plays a key role in
multiple biological processes. However, the regulatory mechanism and functional …