Like all the cells of an organism, pancreatic β-cells originate from embryonic stem cells
through a complex cellular process termed differentiation. Differentiation involves the …

Pancreatic islet beta cells are essential for maintaining glucose homeostasis. To understand
the impact of aging on beta cells, we performed meta-analysis of single-cell RNA …

Cystic fibrosis–related (CF-related) diabetes (CFRD) is an increasingly common and
devastating comorbidity of CF, affecting approximately 35% of adults with CF. However, the …

Objective Dedifferentiation of pancreatic β-cells may reduce islet function in type 2 diabetes
(T2D). However, the prevalence, plasticity and functional consequences of this cellular state …

Dysfunctional pancreatic islet beta cells are a hallmark of type 2 diabetes (T2D), but a
comprehensive understanding of the underlying mechanisms, including gene dysregulation …

Transcriptionally mature and immature β-cells co-exist within the adult islet. How such
diversity contributes to insulin release remains poorly understood. Here we show that subtle …

Background The relationship between pancreatic cancer (PC) and type 2 diabetes mellitus
(T2DM) has long been widely recognized, but the interaction mechanisms are still unknown …

Abstract Context Type 2 diabetes (T2D) and pancreatogenic diabetes are both associated
with loss of functional β-cell mass. Previous studies have proposed β-cell dedifferentiation …

MODY8 (maturity-onset diabetes of the young, type 8) is a dominantly inherited monogenic
form of diabetes associated with mutations in the carboxyl ester lipase (CEL) gene …

Objective As diabetes develops, marked reductions of insulin secretion are associated with
very modest elevations of glucose. We wondered if these glucose changes disrupt beta cell …