Walking a tightrope: the complex balancing act of R-loops in genome stability
JR Brickner, JL Garzon, KA Cimprich - Molecular cell, 2022 - cell.com
Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …
Novel insights into double-stranded RNA-mediated immunopathology
R de Reuver, J Maelfait - Nature Reviews Immunology, 2024 - nature.com
Recent progress in human and mouse genetics has transformed our understanding of the
molecular mechanisms by which recognition of self double-stranded RNA (self-dsRNA) …
molecular mechanisms by which recognition of self double-stranded RNA (self-dsRNA) …
ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation
R de Reuver, S Verdonck, E Dierick, J Nemegeer… - Nature, 2022 - nature.com
The RNA-editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) limits the
accumulation of endogenous immunostimulatory double-stranded RNA (dsRNA). In …
accumulation of endogenous immunostimulatory double-stranded RNA (dsRNA). In …
ADAR1 and its implications in cancer development and treatment
AR Baker, FJ Slack - Trends in Genetics, 2022 - cell.com
The family of adenosine deaminases acting on RNA (ADARs) regulates global gene
expression output by catalyzing adenosine-to-inosine (A-to-I) editing of double-stranded …
expression output by catalyzing adenosine-to-inosine (A-to-I) editing of double-stranded …
DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways
Damage-associated molecular patterns (DAMPs) are endogenous molecules that are
released from host cells as a result of cell death or damage. The release of DAMPs in …
released from host cells as a result of cell death or damage. The release of DAMPs in …
[HTML][HTML] ADAR1 Zα domain P195A mutation activates the MDA5-dependent RNA-sensing signaling pathway in brain without decreasing overall RNA editing
Variants of the RNA-editing enzyme ADAR1 cause Aicardi-Goutières syndrome (AGS), in
which severe inflammation occurs in the brain due to innate immune activation. Here, we …
which severe inflammation occurs in the brain due to innate immune activation. Here, we …
The phenotype of the most common human ADAR1p150 Zα mutation P193A in mice is partially penetrant
Abstract ADAR1‐mediated A‐to‐I RNA editing is a self‐/non‐self‐discrimination mechanism
for cellular double‐stranded RNAs. ADAR mutations are one cause of Aicardi–Goutières …
for cellular double‐stranded RNAs. ADAR mutations are one cause of Aicardi–Goutières …
Endogenous retroelements as alarms for disruptions to cellular homeostasis
Endogenous retroelements are DNA sequences which can duplicate and move to new
locations in the genome. Actively moving endogenous retroelements can be disruptive to the …
locations in the genome. Actively moving endogenous retroelements can be disruptive to the …
An AGS-associated mutation in ADAR1 catalytic domain results in early-onset and MDA5-dependent encephalopathy with IFN pathway activation in the brain
X Guo, RA Steinman, Y Sheng, G Cao… - Journal of …, 2022 - Springer
Abstract Background Aicardi–Goutières syndrome (AGS) is a severe neurodegenerative
disease with clinical features of early-onset encephalopathy and progressive loss of …
disease with clinical features of early-onset encephalopathy and progressive loss of …
Impact of disease-associated mutations on the deaminase activity of ADAR1
The innate immune system relies on molecular sensors to detect distinctive molecular
patterns, including viral double-stranded RNA (dsRNA), which triggers responses resulting …
patterns, including viral double-stranded RNA (dsRNA), which triggers responses resulting …