[HTML][HTML] Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention

LM Butler, Y Perone, J Dehairs, LE Lupien… - Advanced drug delivery …, 2020 - Elsevier
With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

Cannabinoids in the landscape of cancer

N Mangal, S Erridge, N Habib, A Sadanandam… - Journal of cancer …, 2021 - Springer
Introduction Cannabinoids are a group of terpenophenolic compounds derived from the
Cannabis sativa L. plant. There is a growing body of evidence from cell culture and animal …

A guide to targeting the endocannabinoid system in drug design

A Stasiulewicz, K Znajdek, M Grudzień… - International journal of …, 2020 - mdpi.com
The endocannabinoid system (ECS) is one of the most crucial systems in the human
organism, exhibiting multi-purpose regulatory character. It is engaged in a vast array of …

Antimicrobial and cytotoxic effects of cannabinoids: an updated review with future perspectives and current challenges

MA Saleemi, N Yahaya, NNM Zain, M Raoov, YK Yong… - Pharmaceuticals, 2022 - mdpi.com
The development of new antibiotics is urgently needed to combat the threat of bacterial
resistance. New classes of compounds that have novel properties are urgently needed for …

Cannabinoids and prostate cancer: a systematic review of animal studies

K Singh, N Jamshidi, R Zomer, TJ Piva… - International journal of …, 2020 - mdpi.com
Prostate cancer is a major cause of death among men worldwide. Recent preclinical
evidence implicates cannabinoids as powerful regulators of cell growth and differentiation …

[HTML][HTML] Synthetic cannabinoids JWH-018, JWH-122, UR-144 and the phytocannabinoid THC activate apoptosis in placental cells

M Almada, P Alves, BM Fonseca, F Carvalho… - Toxicology letters, 2020 - Elsevier
The increasing use of synthetic cannabinoids (SCBs) in recreational settings is becoming a
new paradigm of drug abuse. Although SCBs effects mimic those of the Cannabis sativa …

Cannabinoids: Potential role in inflammatory and neoplastic skin diseases

R Milando, A Friedman - American journal of clinical dermatology, 2019 - Springer
The endocannabinoid system is a complex and nearly ubiquitous network of endogenous
ligands, enzymes, and receptors that can also be stimulated by exogenous compounds such …

Endocannabinoid system and tumour microenvironment: New intertwined connections for anticancer approaches

M Iozzo, G Sgrignani, G Comito, P Chiarugi… - Cells, 2021 - mdpi.com
The tumour microenvironment (TME) is now recognised as a hallmark of cancer, since
tumour: stroma crosstalk supports the key steps of tumour growth and progression. The …

Targeting CYP2J2 to enhance the anti-glioma efficacy of cannabinoid receptor 2 stimulation by inhibiting the pro-angiogenesis function of M2 microglia

X Lei, X Chen, Y Quan, Y Tao, J Li - Frontiers in oncology, 2020 - frontiersin.org
Enhancing the therapeutic efficacy of anti-tumor drugs is essential for cancer management.
Although cannabinoid receptor 2 (CB2R) stimulation exerts anti-tumor action in glioma cells …

Antitumor cannabinoid chemotypes: Structural insights

P Morales, N Jagerovic - Frontiers in Pharmacology, 2019 - frontiersin.org
Cannabis has long been known to limit or prevent nausea and vomiting, lack of appetite,
and pain. For this reason, cannabinoids have been successfully used in the treatment of …