Sample preparation is a critical and resource-intensive phase of bioanalysis. The centrifuge
is the most commonly used equipment in clinical research and practice for isolating cells …

The liver is a pivotal organ regulating critical developmental stages of fetal metabolism and
detoxification. Though numerous studies have evaluated links between prenatal/perinatal …

Liver metabolism is central to human physiology and influences the pathogenesis of
common metabolic diseases. Yet, our understanding of human liver metabolism remains …

Organotypic three‐dimensional liver spheroid cultures in which hepatic cells retain their
molecular phenotype and functionality have emerged as powerful tools for preclinical drug …

Background: NAFLD is highly prevalent with limited treatment options. Bile acids (BAs)
increase in the systemic circulation and liver during NAFLD progression. Changes in plasma …

Abstract 3D spheroids of primary human hepatocytes (3D PHH) retain a differentiated
phenotype with largely conserved metabolic function and proteomic fingerprint over weeks …

Peroxisome proliferator-activated receptor alpha (PPARα) activation-induced hepatomegaly
is accompanied by hepatocyte hypertrophy around the central vein (CV) area and …

OATP1B facilitates the uptake of xenobiotics into hepatocytes and is a prominent target for
drug–drug interactions (DDIs). Reduced systemic exposure of OATP1B substrates has been …

Distinct hepatocyte subpopulations are spatially segregated along the portal-central axis
and critical to understanding metabolic homeostasis and liver injury. While several bioactive …

The liver contains multiple cell types, including resident cell types and immune cells. The
liver is also categorized into 3 zones: periportal (zone 1), midzonal (zone 2), and …