With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

Cellular senescence is now considered an important driving mechanism for chronic lung
diseases, particularly chronic obstructive pulmonary disease (COPD) and idiopathic …

Sirtuin is an essential factor that delays cellular senescence and extends the organismal
lifespan through the regulation of diverse cellular processes. Suppression of cellular …

Vitamin B3 (nicotinic acid, niacin) deficiency causes the systemic disease pellagra, which
leads to dermatitis, diarrhea, dementia, and possibly death depending on its severity and …

Sirtuin-1 (SIRT1) is a class-III histone deacetylase (HDAC), an NAD+-dependent enzyme
deeply involved in gene regulation, genome stability maintenance, apoptosis, autophagy …

With the aging of global population, the incidence of nonalcoholic fatty liver disease
(NAFLD) has surged in recent decades. NAFLD is a multifactorial disease that follows a …

Aging is associated with a progressive decline in cardiovascular structure and function.
Accumulating evidence links cardiovascular aging to epigenetic alterations encompassing a …

The role of epigenetics in endothelial cell senescence is a cutting-edge topic in ageing
research. However, little is known of the relative contribution to pro-senescence signal …

The high prevalence of gastrointestinal (GI) disorders among autism spectrum disorder
(ASD) patients has prompted scientists to look into the gut microbiota as a putative trigger in …

Ischemic stroke is the second leading cause of death worldwide with limited medications
and neuroinflammation was recognized as a critical player in the progression of stroke, but …