Peroxisomes are subcellular organelles that play a central role in human physiology by
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …

Peroxisomes are key metabolic organelles, which contribute to cellular lipid metabolism, eg
the β-oxidation of fatty acids and the synthesis of myelin sheath lipids, as well as cellular …

Bile acids facilitate the absorption of lipids in the gut, but are also needed to maintain
cholesterol homeostasis, induce bile flow, excrete toxic substances and regulate energy …

In the present study, we discuss the recent developments in oxysterol research. Exciting
results have been reported relating to the involvement of oxysterols in the fields of …

Most of the known enzyme deficiencies of bile acid synthesis affect both the 27-
hydroxycholesterol and the 7α-hydroxycholesterol pathways; the exceptions are cholesterol …

Mitochondrial β-oxidation is the most prominent pathway for fatty acid oxidation but
alternative oxidative metabolism exists. Fatty acid ω-oxidation is one of these pathways and …

Peroxisomal acyl-CoA oxidases catalyze the first step of beta-oxidation of a variety of
substrates broken down in the peroxisome. These include the CoA-esters of very long-chain …

Hepatocellular carcinoma (HCC) has been extensively studied as one of the most
aggressive tumors worldwide. However, its mortality rate remains high due to ideal …

Background Bile acids play important roles in cholesterol metabolism and signal through
farnesoid X receptor and G protein‐coupled receptors. Given their importance in liver …

Peroxisomes play a central role in metabolism as exemplified by the fact that many genetic
disorders in humans have been identified through the years in which there is an impairment …