Tumor-bearing experimental animals are essential for preclinical cancer drug development.
A broad range of tumor models is available, with the simplest and most widely used …

The study of angiogenesis has grown exponentially over the past 40 years with the
recognition that angiogenesis is essential for numerous pathologies and, more recently, with …

Among various gene therapy methods for cancer, suicide gene therapy attracts a special
attention because it allows selective conversion of non-toxic compounds into cytotoxic drugs …

The selective activation of prodrug (s) in tumor tissues by exogenous enzyme (s) for cancer
therapy can be accomplished by several ways, including gene-directed enzyme prodrug …

Angiogenesis, the development of new blood vessels from an existing vasculature, is
essential in normal developmental processes and in numerous pathologies, including …

Anticancer drugs are often nonselective antiproliferative agents (cytotoxins) that
preferentially kill dividing cells by attacking their DNA at some level. The lack of selectivity …

Compared to conventional treatments, gene therapy offers a variety of advantages for
cancer treatment including high potency and specificity, low off-target toxicity, and delivery of …

Gene therapy of cancer is a novel approach with the potential to selectively eradicate tumour
cells, whilst sparing normal tissue from damage. In particular, gene‐directed enzyme …

The principle of using suicide genes for gene directed enzyme prodrug therapy (GDEPT) of
cancer has gained increasing significance during the 20 years since its inception. The astute …

Oncolytic viruses are attractive therapeutics for cancer because they selectively amplify,
through replication and spread, the input dose of virus in the target tumor. To date, clinical …