Small molecule SIRT1 activators for the treatment of aging and age-related diseases

BP Hubbard, DA Sinclair - Trends in pharmacological sciences, 2014 - cell.com
Recent studies in mice have identified single molecules that can delay multiple diseases of
aging and extend lifespan. In theory, such molecules could prevent dozens of diseases …

[HTML][HTML] The pharmacology of resveratrol in animals and humans

EJ Park, JM Pezzuto - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2015 - Elsevier
In addition to thousands of research papers related to resveratrol (RSV), approximately 300
review articles have been published. Earlier research tended to focus on pharmacological …

Resveratrol and inflammatory bowel disease: The evidence so far

S Nunes, F Danesi, D Del Rio, P Silva - Nutrition research reviews, 2018 - cambridge.org
Despite the fact that inflammatory bowel disease (IBD) has still no recognised therapy,
treatments which have proven at least mildly successful in improving IBD symptoms include …

The role of flavonoids in autoimmune diseases: Therapeutic updates

KRR Rengasamy, H Khan, S Gowrishankar… - Pharmacology & …, 2019 - Elsevier
Flavonoids are natural polyphenolic compounds which are included in a panoply of drugs
and used to treat and/or manage human ailments such as metabolic, cardiovascular …

Post-translational modifications of transporters

LC Czuba, KM Hillgren, PW Swaan - Pharmacology & therapeutics, 2018 - Elsevier
Drug transporter proteins are critical to the distribution of a wide range of endogenous
compounds and xenobiotics such as hormones, bile acids, peptides, lipids, sugars, and …

Recent advances on the anti-inflammatory and antioxidant properties of red grape polyphenols: in vitro and in vivo studies

T Magrone, M Magrone, MA Russo, E Jirillo - Antioxidants, 2019 - mdpi.com
In this review, special emphasis will be placed on red grape polyphenols for their antioxidant
and anti-inflammatory activities. Therefore, their capacity to inhibit major pathways …

Dietary phytochemicals modulate intestinal epithelial barrier dysfunction and autoimmune diseases

K Ganesan, JL Quiles, M Daglia, J Xiao, B Xu - Food Frontiers, 2021 - Wiley Online Library
The intestinal epithelium acts as a key defensive barrier that protects internal organs from
the detrimental gut environment. The homeostasis of the gut epithelium may be altered by …

Antioxidant therapy in inflammatory bowel diseases

K Dziąbowska-Grabias, M Sztanke, P Zając… - Antioxidants, 2021 - mdpi.com
Inflammatory bowel diseases (IBD) are a group of chronic, incurable diseases of the
digestive tract, the etiology of which remains unclear to this day. IBD result in significant …

Inhibition of breast cancer metastasis by resveratrol-mediated inactivation of tumor-evoked regulatory B cells

C Lee-Chang, M Bodogai… - The Journal of …, 2013 - journals.aai.org
We reported previously that tumor-evoked regulatory B cells (tBregs) play an essential role
in breast cancer lung metastasis by inducing TGF-β–dependent conversion of metastasis …

Resveratrol role in autoimmune disease—a mini-review

ALB Oliveira, VVS Monteiro, KC Navegantes-Lima… - Nutrients, 2017 - mdpi.com
Autoimmune diseases are still considered to be pressing concerns due the fact that they are
leaders in death and disability causes worldwide. Resveratrol is a polyphenol derived from a …