Progress and challenges in aminoacyl-tRNA synthetase-based therapeutics
CS Francklyn, P Mullen - Journal of Biological Chemistry, 2019 - ASBMB
Aminoacyl-tRNA synthetases (ARSs) are universal enzymes that catalyze the attachment of
amino acids to the 3′ ends of their cognate tRNAs. The resulting aminoacylated tRNAs are …
amino acids to the 3′ ends of their cognate tRNAs. The resulting aminoacylated tRNAs are …
Lead compounds from mangrove-associated microorganisms
E Ancheeva, G Daletos, P Proksch - Marine drugs, 2018 - mdpi.com
The mangrove ecosystem is considered as an attractive biodiversity hotspot that is
intensively studied in the hope of discovering new useful chemical scaffolds, including those …
intensively studied in the hope of discovering new useful chemical scaffolds, including those …
Bacterial pathogens: threat or treat (a review on bioactive natural products from bacterial pathogens)
F Maglangit, Y Yu, H Deng - Natural Product Reports, 2021 - pubs.rsc.org
Covering: up to the second quarter of 2020 Threat or treat? While pathogenic bacteria pose
significant threats, they also represent a huge reservoir of potential pharmaceuticals to treat …
significant threats, they also represent a huge reservoir of potential pharmaceuticals to treat …
Control of the unfolded protein response in health and disease
D Doultsinos, T Avril, S Lhomond… - … Life Sciences R&D, 2017 - journals.sagepub.com
The unfolded protein response (UPR) is an integrated, adaptive biochemical process that is
inextricably linked with cell homeostasis and paramount to maintenance of normal …
inextricably linked with cell homeostasis and paramount to maintenance of normal …
GRP78 influences chemoresistance and prognosis in cancer
JB Gifford, R Hill - Current Drug Targets, 2018 - ingentaconnect.com
Background: Resistance to therapy is a major hindrance to patient survival in cancer,
underscoring a critical need to elucidate the underlying mechanisms responsible for …
underscoring a critical need to elucidate the underlying mechanisms responsible for …
Endoplasmic reticulum stress pathway, the unfolded protein response, modulates immune function in the tumor microenvironment to impact tumor progression and …
MU Ramirez, SR Hernandez, DR Soto-Pantoja… - International Journal of …, 2019 - mdpi.com
Despite advances in cancer therapy, several persistent issues remain. These include cancer
recurrence, effective targeting of aggressive or therapy-resistant cancers, and selective …
recurrence, effective targeting of aggressive or therapy-resistant cancers, and selective …
[HTML][HTML] Borrelidin-producing and root-colonizing Streptomyces rochei is a potent biopesticide for two soil-borne oomycete-caused plant diseases
D Zhou, X Wang, WM Anjago, J Li, W Li, M Li, M Jiu… - Biological Control, 2024 - Elsevier
Biopesticides are an attractive biotechnological alternative to conventional pesticides for soil-
borne plant diseases. A screening strategy with over 100 actinomycetes bacteria isolated …
borne plant diseases. A screening strategy with over 100 actinomycetes bacteria isolated …
[HTML][HTML] Adaptive preconditioning in neurological diseases–therapeutic insights from proteostatic perturbations
B Mollereau, NM Rzechorzek, BD Roussel, M Sedru… - Brain research, 2016 - Elsevier
In neurological disorders, both acute and chronic neural stress can disrupt cellular
proteostasis, resulting in the generation of pathological protein. However in most cases …
proteostasis, resulting in the generation of pathological protein. However in most cases …
Disulfiram (Antabuse) activates ROS-dependent ER stress and apoptosis in oral cavity squamous cell carcinoma
P Shah O'Brien, Y Xi, JR Miller, AL Brownell… - Journal of Clinical …, 2019 - mdpi.com
A paucity of advances in the development of novel therapeutic agents for squamous cell
carcinomas of the head and neck, oral cavity (OSCC) and oropharynx, has stagnated …
carcinomas of the head and neck, oral cavity (OSCC) and oropharynx, has stagnated …
Identification of portimine B, a new cell permeable spiroimine that induces apoptosis in oral squamous cell carcinoma
Spiroimines are a class of compounds produced by marine dinoflagellates with a wide
range of toxicity and therapeutic potential. The smallest of the cyclic imines, portimine, is far …
range of toxicity and therapeutic potential. The smallest of the cyclic imines, portimine, is far …