Transfer RNAs (tRNAs) have a crucial role in protein synthesis, and in recent years, their
therapeutic potential for the treatment of genetic diseases—primarily those associated with a …

Aminoacyl-tRNA synthetases (ARSs) are responsible for charging amino acids to cognate
tRNA molecules, which is the essential first step of protein translation. Interestingly …

Dominant mutations in ubiquitously expressed transfer RNA (tRNA) synthetase genes cause
axonal peripheral neuropathy, accounting for at least six forms of Charcot-Marie-Tooth …

Heterozygous mutations in six transfer RNA (tRNA) synthetase genes cause Charcot-Marie-
Tooth (CMT) peripheral neuropathy. CMT mutant tRNA synthetases inhibit protein synthesis …

Profiling the nascent cellular proteome and capturing early proteomic changes in response
to external stimuli provides valuable insights into cellular physiology. Existing metabolic …

Transfer RNAs (tRNAs) decode messenger RNA codons to peptides at the ribosome. The
nuclear genome contains many tRNA genes for each amino acid and even each anticodon …

A GGGGCC hexanucleotide repeat expansion within the C9orf72 gene is the most common
genetic cause of both amyotrophic lateral sclerosis and frontotemporal dementia. Sense and …

Aging-related neurodegenerative diseases are progressive and fatal neurological diseases
that are characterized by irreversible neuron loss and gliosis. With a growing population of …

Amyotrophic lateral sclerosis (ALS) has substantial heritability, in part shared with fronto-
temporal dementia (FTD). We show that ALS heritability is enriched in splicing variants and …

Aminoacyl-tRNA synthetases (ARSs) are universal enzymes that catalyze the attachment of
amino acids to the 3′ ends of their cognate tRNAs. The resulting aminoacylated tRNAs are …