Alzheimer's Disease (AD) is the most common neurodegenerative disease worldwide, with a
high prevalence that is expected to double every 20 years. Besides the formation of Aβ …

Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …

Therapies targeting late events in Alzheimer's disease (AD), including aggregation of
amyloid beta (Aβ) and hyperphosphorylated tau, have largely failed, probably because they …

Alzheimer's disease (AD) is the most prevalent form of dementia which affects people older
than 60 years of age. In AD, the dysregulation of the amyloid-beta (Aβ) level leads to the …

β‐amyloid (Aβ) is widely accepted to be one of the major pathomechanisms underlying
Alzheimer's disease (AD), although there is presently lively debate regarding the relative …

In Alzheimer's disease (AD), dementia severity correlates strongly with decreased synapse
density in hippocampus and cortex. Numerous studies report that hippocampal long-term …

Astrocytes are glial cells that are distributed throughout the central nervous system in an
arrangement optimal for chemical and physical interaction with neuronal synapses and …

In Alzheimer's disease (AD), the impairment of declarative memory coincides with the
accumulation of extracellular amyloid-β protein (Aβ) and intraneuronal tau aggregates …

Neuroprotective drugs tested in clinical trials, particularly those that block N-methyl-d-
aspartate-sensitive glutamate receptors (NMDARs), have failed miserably in large part …

Alzheimer disease is the most prevalent form of dementia globally and is characterized
premortem by a gradual memory loss and deterioration of higher cognitive functions and …