Summary Sodium-glucose co-transporter 2 (SGLT2) inhibitors, initially developed as a novel
class of anti-hyperglycaemic drugs, have been shown to significantly improve metabolic …

Type 2 diabetes is a disease involving both inadequate insulin levels and increased
glucagon levels. While glucagon and insulin work together to achieve optimal plasma …

Homeostasis maintains serum metabolites within physiological ranges. For glucose, this
requires insulin, which suppresses glucose production while accelerating its consumption …

Certain antimicrobial preservatives (APs) have been shown to perturb gut microbiota. So far,
it is not yet fully known that whether similar effects are observable for a more diverse set of …

Glucagon signaling is essential for maintaining normoglycemia in mammals. The arrestin
fold superfamily of proteins controls the trafficking, turnover, and signaling of transmembrane …

Heart failure (HF) often coexists with insulin resistance (IR), and the incidence of HF in type
2 diabetes mellitus (T2DM) patients is significantly higher. The reciprocal relationship …

Objectives GPR142, which is highly expressed in pancreatic islets, has recently been
deorphanized as a receptor for aromatic amino acids; however, its physiological role and …

Aim The influence of dietary carbohydrates and fats on weight gain is inconclusively
understood. We studied the acute impact of these nutrients on the overall metabolic state …

Context According to the carbohydrate-insulin model of obesity, an elevated insulin-to-
glucagon ratio in response to a high-carbohydrate diet directs metabolic fuels toward …

Context The mechanism mediating sodium glucose cotransporter-2 (SGLT2) inhibitor–
associated increase in glucagon levels is unknown. Objective To assess short-term effects …