Relevance of peroxiredoxins in pathogenic microorganisms

MA de Oliveira, CA Tairum, LES Netto… - Applied Microbiology …, 2021 - Springer
The oxidative and nitrosative responses generated by animals and plants are important
defenses against infection and establishment of pathogenic microorganisms such as …

Typical 2-Cys peroxiredoxins in human parasites: Several physiological roles for a potential chemotherapy target

F Angelucci, AE Miele, M Ardini, G Boumis… - Molecular and …, 2016 - Elsevier
Peroxiredoxins (Prxs) are ubiquitary proteins able to play multiple physiological roles, that
include thiol-dependent peroxidase, chaperone holdase, sensor of H 2 O 2, regulator of H 2 …

A Novel Thioredoxin-Dependent Peroxiredoxin (TPx-Q) Plays an Important Role in Defense Against Oxidative Stress and Is a Possible Drug Target in Babesia microti

H Zhang, Z Wang, J Huang, J Cao, Y Zhou… - Frontiers in Veterinary …, 2020 - frontiersin.org
Thioredoxin peroxidases (TPxs) are ubiquitous cysteine-based peroxidases that reduce
peroxides as part of antioxidant defenses and redox signaling and are essential for Babesia …

Evaluating the Vaccine Potential of a Tetravalent Fusion Protein (rBmHAXT) Vaccine Antigen Against Lymphatic Filariasis in a Mouse Model

N Chauhan, V Khatri, P Banerjee… - Frontiers in …, 2018 - frontiersin.org
Lymphatic filariasis (LF) is a tropical parasitic infection of human transmitted by mosquitoes.
Chronic infection results in severe physical disability in the infected patients. Although …

Does attenuated plasmodial sporozoite-mediated protection require peroxynitrite?

B Douradinha - Trends in Parasitology, 2023 - cell.com
Attenuated plasmodial sporozoite-induced immune response includes intrahepatic nitric
oxide (NO) production, which promotes apoptosis of infected hepatocytes and consequent …

Does hydrogen peroxide contribute to the immunity against Malaria induced by whole attenuated plasmodial sporozoites?

B Douradinha - Molecular and Biochemical Parasitology, 2023 - Elsevier
Plasmodium sporozoites can block apoptotic pathways within host hepatocytes, ensuring
the survival of the parasite. However, attenuated plasmodial sporozoites are unable to …

Identification and functional study of a novel 2-cys peroxiredoxin (BmTPx-1) of Babesia microti

H Zhang, Z Wang, H Gong, J Cao, Y Zhou… - Experimental …, 2016 - Elsevier
Babesia microti is an emerging human pathogen and the primary causative agent of human
babesiosis in many regions of the world. Although the peroxiredoxins (Prxs) or thioredoxin …

Identification of 2-Cys Peroxiredoxin (BmTPx-2) as Antioxidant Active Molecule from Babesia microti

X Hai, H Zhang, Z Wang, H Gong, J Cao… - Frontiers in …, 2017 - frontiersin.org
Peroxiredoxins (Prxs) are a family of antioxidant enzymes that reduce peroxides in the
presence of thioredoxin, thioredoxin reductase, and nicotinamide adenine dinucleotide …

Identifying Merozoite Targets of Protective Immunity Against Plasmodium falciparum Malaria

G Kamuyu - 2017 - oro.open.ac.uk
The observation that individuals living in malaria endemic regions who are repeatedly
infected with P. falciparum can acquire immunity, first to severe, then to uncomplicated …

Identification and functional analysis of a novel mitochondria-localized 2-Cys peroxiredoxin, BbTPx-2, from Babesia bovis

T Masatani, M Asada, H Hakimi, K Hayashi… - Parasitology …, 2016 - Springer
Cysteine-based peroxidases, known as peroxiredoxins (Prx) or thioredoxin peroxidases
(TPx), are important antioxidant enzymes that prevent oxidative damage caused by reactive …