Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

Abstract Streptozotocin (STZ), a glucosamine-nitrosourea compound derived from soil
bacteria and originally developed as an anticancer agent, in 1963 has been found to induce …

Estrogen is a fundamental regulator of the metabolic system of the female brain and body.
Within the brain, estrogen regulates glucose transport, aerobic glycolysis, and mitochondrial …

Tocotrienols, members of the vitamin E family, are natural compounds found in a number of
vegetable oils, wheat germ, barley, and certain types of nuts and grains. Like tocopherols …

Initially discovered in 1938 as a “fertility factor,” vitamin E now refers to eight different
isoforms that belong to two categories, four saturated analogues (α, β, γ, and δ) called …

Alzheimer's disease (AD) is a neurodegenerative disorder representing the major cause of
dementia. It is characterized by memory loss, and cognitive and behavioral decline. In …

Experimental models that faithfully mimic the developmental pathology of sporadic
Alzheimer's disease (sAD) in humans are important for testing the novel therapeutic …

With the advancement of in vivo studies and clinical trials, the pathogenesis of
neurodegenerative diseases has been better understood. However, gaps still need to be …

Memory impairment induced by streptozotocin in rats is a consequence of changes in CNS
that are secondary to chronic hyperglycemia, impaired oxidative stress, cholinergic …

Type 2 diabetes (T2D) is one of the major risk factors associated with Alzheimer's disease
(AD). Recent studies have found similarities in molecular mechanisms that underlie the …