Epigenetic remodeling is a molecular hallmark of gliomas, and it has been identified as a
key mediator of glioma progression. Epigenetic dysregulation contributes to gliomagenesis …

Brain tumors represent the leading cause of disease-related mortality and morbidity in
children, with effective treatments urgently required. One factor limiting the effectiveness of …

Single-cell open chromatin profiling via scATAC-seq has become a mainstream
measurement of open chromatin in single-cells. Here we present epiAneufinder, an …

Glioblastoma (GBM) is one of the deadliest primary brain malignant tumors with a bleak
prognosis. Craniotomy surgical resection followed by radiotherapy and chemotherapy was …

Simple Summary Cancer heterogeneity, which occurs in most cancer patients, has been
known and studied by experienced pathologists since the early 19th century. Intratumoral …

Simple Summary Pediatric high-grade glioma (pHGG) has a dismal prognosis in which the
younger the patient, the more restricted the treatments are, in regard to the incurred risks …

Pediatric high-grade gliomas (pHGGs) are the leading cause of cancer-related deaths in
children in the USA. Sixteen percent of hemispheric pediatric and young adult HGGs encode …

Pediatric brain tumors are the most common solid malignancies in children. Advances in the
treatment of pediatric brain tumors have come in the form of imaging, biopsy, surgical …

The life expectancy of patients with high-grade glioma (HGG) has not improved in decades.
One of the crucial tools to enable future improvement is advanced models that faithfully …

Diffuse high-grade gliomas contain some of the most dangerous human cancers that lack
curative treatment options. The recent molecular stratification of gliomas by the World Health …