The emergence of form and function during mammalian embryogenesis is a complex
process that involves multiple regulatory levels. The foundations of the body plan are laid …

Assisted reproductive technology (ART) includes fertility treatment in which either eggs or
embryos are handled outside a female's body to promote successful pregnancies and …

Understanding human development is of fundamental biological and clinical importance.
Despite its significance, mechanisms behind human embryogenesis remain largely …

Following implantation, the human embryo undergoes major morphogenetic transformations
that establish the future body plan. While the molecular events underpinning this process …

Human blastocysts are comprised of the first three cell lineages of the embryo:
trophectoderm, epiblast and primitive endoderm, all of which are essential for early …

Cellular dynamics and fate decision in early human embryogenesis remain largely unknown
owing to the challenges of performing studies in human embryos. Here, we explored whole …

Human preimplantation development involves extensive remodeling of RNA expression and
splicing. However, its transcriptome has been compiled using short-read sequencing data …

The peri-implantation window of mammalian development is the crucial window for
primordial germ cell (PGC) specification. Whereas pre-implantation dynamics are relatively …

Embryonic development is largely conserved among mammals. However, certain genes
show divergent functions. By generating a transcriptional atlas containing> 30,000 cells from …

Too many choices can be problematic. This is certainly the case for human pluripotent stem
cells (hPSCs): they harbor the potential to differentiate into hundreds of cell types; yet it is …