Filamin C (FLNC) is one of three filamin proteins (Filamin A (FLNA), Filamin B (FLNB), and
FLNC) that cross-link actin filaments and interact with numerous binding partners. FLNC …

The balance of ubiquitination and deubiquitination plays diverse roles in regulating protein
stability and cellular homeostasis. Deubiquitinating enzymes catalyze the hydrolysis and …

Vertebrates express two distinct families of SUMO proteins (SUMO1 and SUMO2/3) that
serve distinct functions as posttranslational modifiers. Many proteins are modified …

Abstract Interleukin 17 (IL-17) is important in infection and autoimmunity; how it signals
remains poorly understood. In this study, we identified the ubiquitin-specific protease USP25 …

Cell-type-specific splicing generates numerous alternatively spliced transcripts playing
important roles for organ development and homeostasis, but only a few tissue-specific …

The ubiquitin–proteasome system facilitates the degradation of damaged proteins and
regulators of growth and stress response. Alterations in this proteolytic system are …

Host pathogen-recognition receptors detect nucleic acid from invading viruses and initiate a
series of signaling pathways that lead to the production of type I interferons (IFNs) and …

Down syndrome (DS), caused by trisomy of chromosome 21, is the most significant risk
factor for early-onset Alzheimer's disease (AD); however, underlying mechanisms linking DS …

Background Growing evidence indicates that miR-200c is involved in carcinogenesis and
tumor progression in non-small-cell lung cancer (NSCLC). However, its precise biological …

Protein ubiquitination plays a critical role in Toll-like receptor (TLR) signaling and innate
immunity. Although several E3 ubiquitin ligases have been identified downstream of TLRs …