The members of the Management and Therapy Subcommittee undertook an evidence-
based review of current dry eye therapies and management options. Management options …

Mitochondrial permeability transition, as the consequence of opening of a mitochondrial
permeability transition pore (mPTP), is a cellular catastrophe. Initiating bioenergetic collapse …

Background Pharmacogenetics is not a new subject area but its relevance to drug
prescribing has become clearer in recent years due to developments in gene cloning and …

Patients undergoing treatment with immunosuppressant drugs following solid organ or
hematopoietic stem cell transplantation are at particular risk for development of serious …

Recombinant adeno-associated virus (rAAV) has attracted a significant research focus for
delivering genetic therapies to target cells. This non-enveloped virus has been trialed in …

Tacrolimus is a commonly used immunosuppressant after kidney transplantation. It has a
narrow therapeutic range and demonstrates wide interindividual variability in …

Cyclosporin-A has been known and used for a long time, since its “fast track” approval in the
early 80's. This molecule has rapidly demonstrated unexpected immunosuppressive …

Background Inflammatory bowel disease (IBD) is a chronic relapsing-remitting disease. An
adverse immune reaction toward the intestinal microbiota is involved in the pathophysiology …

Aim Several tacrolimus population pharmacokinetic models in adult renal transplant
recipients have been established to facilitate dose individualization. However, their …

This review summarises the available data on the population pharmacokinetics of tacrolimus
and use of Maximum A Posteriori (MAP) Bayesian estimation to predict tacrolimus exposure …